Mini Review: Molecular Interpretation of the IGF/IGF-1R Axis in Cancer Treatment and Stem Cells-Based Therapy in Regenerative Medicine

In addition to the fundamental role of insulin-like growth factor (IGF)/IGF-1 receptor (IGF-1R) signaling dysregulation in cancer initiation and proliferation, the IGF/IGF-1R signaling also plays an important role in the maintenance of stem cell characteristics and enhancement of stem cell-based the...

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Published inInternational journal of molecular sciences Vol. 23; no. 19; p. 11781
Main Authors Lin, Syuan-Ling, Lin, Chih-Yang, Lee, Wei, Teng, Chiao-Fang, Shyu, Woei-Cherng, Jeng, Long-Bin
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 01.10.2022
MDPI
Subjects
Binding sites
Breast cancer
cancer
Cancer therapies
Cell growth
Cell self-renewal
Chemotherapy
Clinical trials
Colorectal cancer
Endocrine disorders
Ewings sarcoma
Fibroblasts
Growth factors
IGF
IGF-1R
Insulin
Insulin resistance
Insulin-like growth factor I
Insulin-like growth factors
Kinases
Ligands
Medical prognosis
Metastasis
Monoclonal antibodies
Phosphorylation
Pluripotency
Protein-tyrosine kinase
Regenerative medicine
Review
Reviews
stem cell therapy
Stem cells
Tumors
Tyrosine
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Summary:In addition to the fundamental role of insulin-like growth factor (IGF)/IGF-1 receptor (IGF-1R) signaling dysregulation in cancer initiation and proliferation, the IGF/IGF-1R signaling also plays an important role in the maintenance of stem cell characteristics and enhancement of stem cell-based therapeutic efficacy. This review focused on the role of IGF/IGF-1R signaling in preclinical IGF-targeted therapies, including IGF-1R monoclonal antibodies, IGF-1R tyrosine kinase inhibitors, and neutralizing antibodies of IGFs in multiple tumors and endocrine disorders. On the other hand, the function of IGF/IGF-1R signaling in stem cell self-renewal, pluripotency and therapeutic efficacy in regenerative medicine was outlined. Finally, the review summarized ongoing studies on IGF/IGF-1R signaling blockade in multiple cancers and highlighted the IGF-1R signaling modifications in stem cells as a potential strategy to improve stem cell-based therapeutics in regenerative medicine.
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These authors contributed equally to this work.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms231911781