Monitoring Therapeutic Responses to Silicified Cancer Cell Immunotherapy Using PET/MRI in a Mouse Model of Disseminated Ovarian Cancer

Current imaging approaches used to monitor tumor progression can lack the ability to distinguish true progression from pseudoprogression. Simultaneous metabolic 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) positron emission tomography (PET) and magnetic resonance imaging (MRI) offers new opportunities...

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Published inInternational journal of molecular sciences Vol. 23; no. 18; p. 10525
Main Authors Taylor, Erik N., Wilson, Colin M., Franco, Stefan, De May, Henning, Medina, Lorél Y., Yang, Yirong, Flores, Erica B., Bartee, Eric, Selwyn, Reed G., Serda, Rita E.
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 10.09.2022
MDPI
Subjects
Abdomen
Ascites
Bioluminescence
Body fat
Cancer immunotherapy
cancer vaccine
Cancer vaccines
cell silicification
Flow cytometry
Fluorine isotopes
Glucose
Histopathology
Immune system
Immunotherapy
Ligands
Longitudinal studies
Lymphocytes
Magnetic resonance imaging
Medical imaging
Mesentery
Metastasis
Monitoring
MRI
Ovarian cancer
PET
Positron emission
Positron emission tomography
Telemedicine
Tomography
Tumor cells
Tumor microenvironment
Tumors
Vaccines
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Summary:Current imaging approaches used to monitor tumor progression can lack the ability to distinguish true progression from pseudoprogression. Simultaneous metabolic 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) positron emission tomography (PET) and magnetic resonance imaging (MRI) offers new opportunities to overcome this challenge by refining tumor identification and monitoring therapeutic responses to cancer immunotherapy. In the current work, spatial and quantitative analysis of tumor burden were performed using simultaneous [18F]FDG-PET/MRI to monitor therapeutic responses to a novel silicified cancer cell immunotherapy in a mouse model of disseminated serous epithelial ovarian cancer. Tumor progression was validated by bioluminescence imaging of luciferase expressing tumor cells, flow cytometric analysis of immune cells in the tumor microenvironment, and histopathology. While PET demonstrated the presence of metabolically active cancer cells through [18F]FDG uptake, MRI confirmed cancer-related accumulation of ascites and tissue anatomy. This approach provides complementary information on disease status without a confounding signal from treatment-induced inflammation. This work provides a possible roadmap to facilitate accurate monitoring of therapeutic responses to cancer immunotherapies.
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These authors contributed equally to this work.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms231810525