DC homeostasis in hematopoietic stem cell transplantation

Hematopoietic stem cell transplantation is an important experimental tool and therapeutic modality. Its efficacy and toxicity are both linked to a GvH reaction that is initiated by donor T cells recognizing recipient APC, of which DC are the most potent. In most tissues recipient DC are replaced aft...

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Bibliographic Details
Published inCytotherapy (Oxford, England) Vol. 9; no. 6; pp. 521 - 531
Main Authors Collin, M.P, Bogunovic, M, Merad, M
Format Journal Article
LanguageEnglish
Published England Elsevier Inc 2007
Informa UK Ltd
Subjects
Advanced Basic Science
Animals
Antigen-Presenting Cells - cytology
dendritic cell
Dendritic Cells - physiology
graft versus host disease
Graft vs Host Reaction
Hematopoietic Stem Cell Transplantation
Homeostasis
Humans
Other
stem cell transplantation
homeostasis
stem cell transplantation
dendritic cell
graft versus host disease
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Summary:Hematopoietic stem cell transplantation is an important experimental tool and therapeutic modality. Its efficacy and toxicity are both linked to a GvH reaction that is initiated by donor T cells recognizing recipient APC, of which DC are the most potent. In most tissues recipient DC are replaced after transplantation because they turnover rapidly from BM-derived precursors. However, in a number of sites, notably the skin, recipient DC may persist and even self-renew for many months after transplantation. Understanding the homeostasis of different APC populations and how they are related to the induction of alloreactivity may help to improve the therapeutic benefit of transplantation.
ISSN:1465-3249
1477-2566
DOI:10.1080/14653240701507314