Contraction-induced oxidants as mediators of adaptation and damage in skeletal muscle

Contracting skeletal muscle generates reactive oxygen and nitrogen species (ROS) that can induce changes in gene expression or cell damage depending upon the pattern of production and the endogenous protective systems. The hypothesis is presented that skeletal muscle uses contraction-induced ROS as...

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Bibliographic Details
Published inExercise and sport sciences reviews Vol. 32; no. 1; p. 14
Main Authors Pattwell, David M, Jackson, Malcolm J
Format Journal Article
LanguageEnglish
Published United States 01.01.2004
Subjects
Adaptation, Physiological
Biomarkers - analysis
Homeostasis
Humans
Muscle Contraction - physiology
Muscle, Skeletal - injuries
Muscle, Skeletal - metabolism
Oxidation-Reduction
Reactive Nitrogen Species - metabolism
Reactive Oxygen Species - analysis
Reactive Oxygen Species - metabolism
Sensitivity and Specificity
Signal Transduction
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Summary:Contracting skeletal muscle generates reactive oxygen and nitrogen species (ROS) that can induce changes in gene expression or cell damage depending upon the pattern of production and the endogenous protective systems. The hypothesis is presented that skeletal muscle uses contraction-induced ROS as signals to induce adaptive responses including maintenance of oxidant homeostasis and prevention of oxidative damage.
ISSN:0091-6331
DOI:10.1097/00003677-200401000-00004