Exploring the role of bacterial virulence factors and host elements in septic arthritis: insights from animal models for innovative therapies
Septic arthritis, characterized as one of the most aggressive joint diseases, is primarily attributed to ( ) and often results from hematogenous dissemination. Even with prompt treatment, septic arthritis frequently inflicts irreversible joint damage, leading to sustained joint dysfunction in a sign...
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Published in | Frontiers in microbiology Vol. 15; p. 1356982 |
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Main Author | |
Format | Journal Article |
Language | English |
Published |
Switzerland
Frontiers Media S.A
2024
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Subjects | |
Online Access | Get full text |
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Summary: | Septic arthritis, characterized as one of the most aggressive joint diseases, is primarily attributed to
(
) and often results from hematogenous dissemination. Even with prompt treatment, septic arthritis frequently inflicts irreversible joint damage, leading to sustained joint dysfunction in a significant proportion of patients. Despite the unsatisfactory outcomes, current therapeutic approaches for septic arthritis have remained stagnant for decades. In the clinical context, devising innovative strategies to mitigate joint damage necessitates a profound comprehension of the pivotal disease mechanisms. This entails unraveling how bacterial virulence factors interact with host elements to facilitate bacterial invasion into the joint and identifying the principal drivers of joint damage. Leveraging animal models of septic arthritis emerges as a potent tool to achieve these objectives. This review provides a comprehensive overview of the historical evolution and recent advancements in septic arthritis models. Additionally, we address practical considerations regarding experimental protocols. Furthermore, we delve into the utility of these animal models, such as their contribution to the discovery of novel bacterial virulence factors and host elements that play pivotal roles in the initiation and progression of septic arthritis. Finally, we summarize the latest developments in novel therapeutic strategies against septic arthritis, leveraging insights gained from these unique animal models. |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 Elysia A. Masters, U.S. Food and Drug Administration, United States Neil Zhao, Thomas Jefferson University, United States Edited by: Axel Cloeckaert, Institut National de recherche pour l’agriculture, l’alimentation et l’environnement (INRAE), France Reviewed by: Lynn Pezzanite, Colorado State University, United States |
ISSN: | 1664-302X 1664-302X |
DOI: | 10.3389/fmicb.2024.1356982 |