Editorial: Molecular mechanisms of nociception

Conversely, a better knowledge of the mechanism of action of efficacious analgesic could allow to target specific neuronal subpopulation and/or pathways. [...]Ma et al. observed that the population of Trpv1 and Oprm1 co-expressing neurons may explain the remarkable efficacy of opioid drugs administe...

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Published inFrontiers in molecular neuroscience Vol. 15; p. 1025230
Main Authors Goudet, Cyril, Marchand, Fabien
Format Journal Article
LanguageEnglish
Published Lausanne Frontiers Research Foundation 06.09.2022
Frontiers Media
Frontiers Media S.A
Subjects
analgesic
Analgesics
Animal models
Brain research
Capsaicin receptors
Chronic pain
Conflicts of interest
Drug development
Life Sciences
Molecular modelling
Molecular Neuroscience
Mutation
Neurobiology
Neurons and Cognition
nociception
Pain
Pain perception
physiopathologic mechanism
Therapeutic targets
France
nociception
pain
chronic pain
therapeutic targets
physiopathologic mechanism
analgesic
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Summary:Conversely, a better knowledge of the mechanism of action of efficacious analgesic could allow to target specific neuronal subpopulation and/or pathways. [...]Ma et al. observed that the population of Trpv1 and Oprm1 co-expressing neurons may explain the remarkable efficacy of opioid drugs administered at the level of the DRG-spinal synapse, and that this subpopulation of Trpv1+ neurons is responsible for registering tissue damage. [...]relevant rodent models of chronic pain inspired by patients will definitely help to improve the translational quality of preclinical studies. [...]we hope that this Research Topic, which covers a large spectrum of nociceptive mechanisms, will be useful for scientists interested in understanding the physiopathology of chronic pain and the identification of potential therapeutic targets.
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This article was submitted to Pain Mechanisms and Modulators, a section of the journal Frontiers in Molecular Neuroscience
Edited and reviewed by: Robert John Vandenberg, The University of Sydney, Australia
ISSN:1662-5099
1662-5099
DOI:10.3389/fnmol.2022.1025230