Methods to monitor accurate and consistent electrode placements in conventional transcranial electrical stimulation

• Published in: Brain stimulation Vol. 12; no. 2; pp. 267 - 274
• Main Authors: Indahlastari, Aprinda, Albizu, Alejandro, Nissim, Nicole R., Traeger, Kelsey R., O'Shea, Andrew, Woods, Adam J.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.03.2019
• Subjects: Adult; Brain - physiology; Electrode drift; Electrode placements; Electrodes - standards; Humans; Male; Quality control; Reproducibility of Results; tES; Transcranial Direct Current Stimulation - methods; Transcranial Direct Current Stimulation - standards; Electrode drift; tES; Electrode placements; Quality control
• ISSN: 1935-861X; 1876-4754; 1876-4754
• DOI: 10.1016/j.brs.2018.10.016

Inaccurate electrode placement and electrode drift during a transcranial electrical stimulation (tES) session have been shown to alter predicted field distributions in the brain and thus may contribute to a large variation in tES study outcomes. Currently, there is no objective and independent measure to quantify electrode placement accuracy/drift in tES clinical studies. We proposed and tested novel methods to quantify accurate and consistent electrode placements in tES using models generated from a 3D scanner. Accurate electrode placements were quantified as Discrepancy in eight tES participants by comparing landmark distances of physical electrode locations F3/F4 to their model counterparts. Distances in models were computed using curve and linear based methods. Variability of landmark locations in a single subject was computed for multiple stimulation sessions to determine consistent electrode placements across four experimenters. We obtained an average of 0.4 cm in Discrepancy, which was within the placement accuracy/drift threshold (1 cm) for conventional tES electrodes (∼35 cm2) to achieve reliable tES sessions suggested in the literature. Averaged Variability was 5.2%, with F4 electrode location as the least consistent placement. These methods provide objective feedback for experimenters on their performance in placing tES electrodes. Applications of these methods can be used to monitor electrode locations in tES studies of a larger cohort using F3/F4 montage and other conventional electrode arrangements. Future studies may include co-registering the landmark locations with imaging-derived head models to quantify the effects of electrode accuracy/drift on predicted field distributions in the brain. •Inaccurate electrode placements may affect observed tES outcomes.•We proposed new methods to monitor accurate and consistent tES electrode location.•Our methods were proved useful to detect electrode drift in tES participants.•Our methods can be used as quality control for more reliable tES studies.