The effect of elevated progesterone levels before oocyte retrieval in women undergoing ovarian stimulation for IVF treatment on the genomic profile of peri-implantation endometrium
•The impact of high Progesterone on genomic profile of the endometrium at the time of implantation was examined.•It confirms the importance of obtaining Progesterone measurement on two consecutive days prior to oocyte recovery.•The major pathway affected is NK cell mediated cytotoxicity. To evaluate...
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| Published in | Journal of reproductive immunology Vol. 121; pp. 17 - 25 |
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| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
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Elsevier B.V
01.06.2017
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| Abstract | •The impact of high Progesterone on genomic profile of the endometrium at the time of implantation was examined.•It confirms the importance of obtaining Progesterone measurement on two consecutive days prior to oocyte recovery.•The major pathway affected is NK cell mediated cytotoxicity.
To evaluate the effects of high progesterone prior to oocyte retrieval on the genomic profile of peri-implantation endometrium, we conducted this single-center, prospective cohort study. Depending on whether or not the progesterone level on the day of hCG administration and the day after hCG administration were elevated, a total of 20 women undergoing IVF treatment who did not have fresh embryo transfer were included: Group 1 refers to subjects with normal progesterone level on both days; Group 2 refers to subjects with normal progesterone level on the day of hCG administration and high progesterone level on the day after hCG administration; Group 3 refers to subjects with high progesterone level on the day of hCG administration and normal progesterone level on the day after hCG administration; Group 4 refers to subjects with high progesterone level on both days. Five subjects were included in each group. Endometrial samples were obtained 7days after hCG administration. We found that high progesterone level prior to oocyte retrieval predominantly affected components of the NK cell mediated cytotoxicity pathway in the endometrium and that significant differences were only seen when progesterone measurements on both the day of and day after hCG administration were considered together. |
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| AbstractList | Highlights • The impact of high Progesterone on genomic profile of the endometrium at the time of implantation was examined. • It confirms the importance of obtaining Progesterone measurement on two consecutive days prior to oocyte recovery. • The major pathway affected is NK cell mediated cytotoxicity. To evaluate the effects of high progesterone prior to oocyte retrieval on the genomic profile of peri-implantation endometrium, we conducted this single-center, prospective cohort study. Depending on whether or not the progesterone level on the day of hCG administration and the day after hCG administration were elevated, a total of 20 women undergoing IVF treatment who did not have fresh embryo transfer were included: Group 1 refers to subjects with normal progesterone level on both days; Group 2 refers to subjects with normal progesterone level on the day of hCG administration and high progesterone level on the day after hCG administration; Group 3 refers to subjects with high progesterone level on the day of hCG administration and normal progesterone level on the day after hCG administration; Group 4 refers to subjects with high progesterone level on both days. Five subjects were included in each group. Endometrial samples were obtained 7days after hCG administration. We found that high progesterone level prior to oocyte retrieval predominantly affected components of the NK cell mediated cytotoxicity pathway in the endometrium and that significant differences were only seen when progesterone measurements on both the day of and day after hCG administration were considered together.To evaluate the effects of high progesterone prior to oocyte retrieval on the genomic profile of peri-implantation endometrium, we conducted this single-center, prospective cohort study. Depending on whether or not the progesterone level on the day of hCG administration and the day after hCG administration were elevated, a total of 20 women undergoing IVF treatment who did not have fresh embryo transfer were included: Group 1 refers to subjects with normal progesterone level on both days; Group 2 refers to subjects with normal progesterone level on the day of hCG administration and high progesterone level on the day after hCG administration; Group 3 refers to subjects with high progesterone level on the day of hCG administration and normal progesterone level on the day after hCG administration; Group 4 refers to subjects with high progesterone level on both days. Five subjects were included in each group. Endometrial samples were obtained 7days after hCG administration. We found that high progesterone level prior to oocyte retrieval predominantly affected components of the NK cell mediated cytotoxicity pathway in the endometrium and that significant differences were only seen when progesterone measurements on both the day of and day after hCG administration were considered together. •The impact of high Progesterone on genomic profile of the endometrium at the time of implantation was examined.•It confirms the importance of obtaining Progesterone measurement on two consecutive days prior to oocyte recovery.•The major pathway affected is NK cell mediated cytotoxicity. To evaluate the effects of high progesterone prior to oocyte retrieval on the genomic profile of peri-implantation endometrium, we conducted this single-center, prospective cohort study. Depending on whether or not the progesterone level on the day of hCG administration and the day after hCG administration were elevated, a total of 20 women undergoing IVF treatment who did not have fresh embryo transfer were included: Group 1 refers to subjects with normal progesterone level on both days; Group 2 refers to subjects with normal progesterone level on the day of hCG administration and high progesterone level on the day after hCG administration; Group 3 refers to subjects with high progesterone level on the day of hCG administration and normal progesterone level on the day after hCG administration; Group 4 refers to subjects with high progesterone level on both days. Five subjects were included in each group. Endometrial samples were obtained 7days after hCG administration. We found that high progesterone level prior to oocyte retrieval predominantly affected components of the NK cell mediated cytotoxicity pathway in the endometrium and that significant differences were only seen when progesterone measurements on both the day of and day after hCG administration were considered together. To evaluate the effects of high progesterone prior to oocyte retrieval on the genomic profile of peri-implantation endometrium, we conducted this single-center, prospective cohort study. Depending on whether or not the progesterone level on the day of hCG administration and the day after hCG administration were elevated, a total of 20 women undergoing IVF treatment who did not have fresh embryo transfer were included: Group 1 refers to subjects with normal progesterone level on both days; Group 2 refers to subjects with normal progesterone level on the day of hCG administration and high progesterone level on the day after hCG administration; Group 3 refers to subjects with high progesterone level on the day of hCG administration and normal progesterone level on the day after hCG administration; Group 4 refers to subjects with high progesterone level on both days. Five subjects were included in each group. Endometrial samples were obtained 7days after hCG administration. We found that high progesterone level prior to oocyte retrieval predominantly affected components of the NK cell mediated cytotoxicity pathway in the endometrium and that significant differences were only seen when progesterone measurements on both the day of and day after hCG administration were considered together. |
| Author | Huang, Jin Liu, Liu Li, Tin Chiu Zhang, Songying Tong, Xiao Mei Laird, Susan Dai, Yong Dong Hong, Xu Tao Zhu, Hai Yan |
| Author_xml | – sequence: 1 givenname: Liu surname: Liu fullname: Liu, Liu organization: Center of Reproductive Medicine, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, China – sequence: 2 givenname: Jin surname: Huang fullname: Huang, Jin organization: Department of Obstetrics & Gynecology, Chinese University of Hong Kong, Hong Kong SAR, China – sequence: 3 givenname: Tin Chiu surname: Li fullname: Li, Tin Chiu organization: Department of Obstetrics & Gynecology, Chinese University of Hong Kong, Hong Kong SAR, China – sequence: 4 givenname: Xu Tao surname: Hong fullname: Hong, Xu Tao organization: Zhejiang California International Nanosystems Institute, Zhejiang University, Hangzhou 310058, China – sequence: 5 givenname: Susan surname: Laird fullname: Laird, Susan organization: Biomedical Research Center, Sheffield Hallamshire University, Sheffield, England, UK – sequence: 6 givenname: Yong Dong surname: Dai fullname: Dai, Yong Dong organization: Center of Reproductive Medicine, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, China – sequence: 7 givenname: Xiao Mei surname: Tong fullname: Tong, Xiao Mei organization: Center of Reproductive Medicine, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, China – sequence: 8 givenname: Hai Yan surname: Zhu fullname: Zhu, Hai Yan organization: Center of Reproductive Medicine, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, China – sequence: 9 givenname: Songying surname: Zhang fullname: Zhang, Songying email: zhangsongying@126.com organization: Center of Reproductive Medicine, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, China |
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| Snippet | •The impact of high Progesterone on genomic profile of the endometrium at the time of implantation was examined.•It confirms the importance of obtaining... Highlights • The impact of high Progesterone on genomic profile of the endometrium at the time of implantation was examined. • It confirms the importance of... To evaluate the effects of high progesterone prior to oocyte retrieval on the genomic profile of peri-implantation endometrium, we conducted this... |
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| SubjectTerms | Adult Cytotoxicity, Immunologic Embryo Implantation Endometrium Endometrium - physiology Female Fertilization in Vitro Gene Expression Profiling Genome - genetics Humans IVF Killer Cells, Natural - immunology Obstetrics and Gynecology Oocyte Retrieval Ovulation Induction Peri-implantation Pregnancy Progesterone Progesterone - metabolism Prospective Studies uNK cell |
| Title | The effect of elevated progesterone levels before oocyte retrieval in women undergoing ovarian stimulation for IVF treatment on the genomic profile of peri-implantation endometrium |
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