Metabolic Reprogramming in COVID-19

Plenty of research has revealed virus induced alternations in metabolic pathways, which is known as metabolic reprogramming. Studies focusing on COVID-19 have uncovered significant changes in metabolism, resulting in the perspective that COVID-19 is a metabolic disease. Reprogramming of amino acid,...

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Bibliographic Details
Published inInternational journal of molecular sciences Vol. 22; no. 21; p. 11475
Main Authors Shen, Tao, Wang, Tingting
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 01.11.2021
MDPI
Subjects
Alternations
arginine
Chemical compounds
Cholesterol
Coronaviruses
COVID-19
glucose
Immune response
metabolic changes
Metabolic disorders
Metabolic pathways
Metabolites
Pathophysiology
Pharmacology
Review
tryptophan
Viral diseases
Viruses
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Summary:Plenty of research has revealed virus induced alternations in metabolic pathways, which is known as metabolic reprogramming. Studies focusing on COVID-19 have uncovered significant changes in metabolism, resulting in the perspective that COVID-19 is a metabolic disease. Reprogramming of amino acid, glucose, cholesterol and fatty acid is distinctive characteristic of COVID-19 infection. These metabolic changes in COVID-19 have a critical role not only in producing energy and virus constituent elements, but also in regulating immune response, offering new insights into COVID-19 pathophysiology. Remarkably, metabolic reprogramming provides great opportunities for developing novel biomarkers and therapeutic agents for COVID-19 infection. Such novel agents are expected to be effective adjuvant therapies. In this review, we integrate present studies about major metabolic reprogramming in COVID-19, as well as the possibility of targeting reprogrammed metabolism to combat virus infection.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms222111475