The molecular basis of innate immunity in the horseshoe crab

During the past two decades, the molecular structures and functions have been established for various defense molecules, using horseshoe crab (limulus) as a model animal. These defense molecules include clotting factors, proteinase inhibitors, lectins, antimicrobial peptides and other humoral factor...

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Bibliographic Details
Published inCurrent Opinion in Immunology Vol. 14; no. 1; pp. 87 - 95
Main Author Iwanaga, Sadaaki
Format Book Review Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.02.2002
Subjects
amebocyte
Animals
antimicrobial peptides
C-reactive protein
clotting factors
coagulogen
Defensins - immunology
hemocyte
Horseshoe crab
Horseshoe Crabs - immunology
Immunity, Innate
Lectins - immunology
Limulus
Limulus polyphemus
Marine
tachylectin
tachyplesins
Horseshoe crab
limulus
C-reactive protein
Immunology
amebocyte
clotting factors
tachylectin
coagulogen
Evolution
hemocyte
tachyplesins
antimicrobial peptides
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Summary:During the past two decades, the molecular structures and functions have been established for various defense molecules, using horseshoe crab (limulus) as a model animal. These defense molecules include clotting factors, proteinase inhibitors, lectins, antimicrobial peptides and other humoral factors found mainly in the hemolymph. These components of the cellular and humoral systems, which together comprise innate immunity, defend horseshoe crab effectively from invading microbes. The horseshoe crab has served as a valuable model for studying defense against infection in invertebrates and has given useful insights into innate immunity in mammals.
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ISSN:0952-7915
1879-0372
DOI:10.1016/S0952-7915(01)00302-8