A Comprehensive Analysis of Immunohistochemical Studies in Intrahepatic Cholangiocarcinoma Using the Survival Tree Model

• Published in: Oncology Vol. 76; no. 4; pp. 293 - 300
• Main Authors: Iguchi, Tomohiro, Yamashita, Natsumi, Aishima, Shinichi, Kuroda, Yousuke, Terashi, Takahiro, Sugimachi, Keishi, Taguchi, Ken-ichi, Taketomi, Akinobu, Maehara, Yoshihiko, Tsuneyoshi, Masazumi
• Format: Journal Article
• Language: English
• Published: Basel, Switzerland Karger 01.01.2009; S. Karger AG
• Subjects: Adult; Aged; Aged, 80 and over; Bile Duct Neoplasms - chemistry; Bile Duct Neoplasms - mortality; Bile Duct Neoplasms - pathology; Bile Duct Neoplasms - surgery; Bile Ducts, Intrahepatic; Biological and medical sciences; Cancer; Cholangiocarcinoma - chemistry; Cholangiocarcinoma - mortality; Cholangiocarcinoma - pathology; Cholangiocarcinoma - surgery; Clinical Translational Research; Female; Gastroenterology. Liver. Pancreas. Abdomen; Humans; Immunohistochemistry; Liver diseases; Liver. Biliary tract. Portal circulation. Exocrine pancreas; Male; Medical prognosis; Medical sciences; Middle Aged; Oncology; Prognosis; Survival Analysis; Tumors; Tenascin; Osteopontin; Ki-67; Cholangiocarcinoma; Survival tree model; Immunohistochemistry; Tree algorithm; Biological marker; Hepatic disease; Malignant tumor; Biliary tract disease; Survival; Anatomic pathology; Cancerology; Malignant cholangioma; Ki67 antigen; Digestive diseases; Intrahepatic; Cancer
• ISSN: 0030-2414; 1423-0232
• DOI: 10.1159/000207506

Objective: Various immunohistochemical studies have been performed regarding intrahepatic cholangiocarcinoma (ICC), including the cell cycle-related proteins (p27, cyclin D1, 14-3-3σ, p53, cyclin B1 and Ki-67), the proto-oncogenes (c-erbB-2 and c-Met), the extracellular matrix proteins (tenascin and laminin) and others (β-catenin, epidermal growth factor receptor, osteopontin, aquaporin 1, MUC5AC and fascin). Nevertheless, none of these have been proven to be a predictive power of the prognosis with high specificity and sensitivity for ICC. Methods: Sixty-one patients with ICC were selected and ICC specimens were immunohistochemically stained with the above 16 markers, as previously reported. Results: The immunoreactivity of osteopontin, tenascin and Ki-67 divided the patients with ICC into 4 subgroups by the survival tree model. There was a significant relationship between the location of the tumor, TNM classification, histological differentiation, tumor size, lymphatic permeation, perineural invasion, lymph node metastasis, intrahepatic metastasis and viral infection among the 4 subgroups. In addition, there was a significant difference in survival among the 4 subgroups. Conclusion: In this study, the subgrouping by the survival tree model might be helpful for predicting the patients’ prognosis in ICC.