Applications of transketolases in organic synthesis

The enzyme transketolase has been employed as a catalyst for asymmetric carbon–carbon bond formation in the synthesis of biologically important molecules. A number of important parameters have been addressed including substrate specificity, over-expression of the protein in suitable host systems, sc...

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Bibliographic Details
Published inCurrent opinion in biotechnology Vol. 11; no. 6; pp. 527 - 531
Main Author Turner, Nicholas J
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.12.2000
Subjects
biotransformation
Chemistry, Organic - methods
Organic Chemicals - metabolism
transketolase
Transketolase - metabolism
biotransformation
transketolase
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Summary:The enzyme transketolase has been employed as a catalyst for asymmetric carbon–carbon bond formation in the synthesis of biologically important molecules. A number of important parameters have been addressed including substrate specificity, over-expression of the protein in suitable host systems, scale-up of the reaction and use of transketolase in multi-enzyme experiments. X-ray structural studies have been used to probe the origin of the asymmetry of the carbon–carbon bond-forming process.
Bibliography:ObjectType-Article-2
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ISSN:0958-1669
1879-0429
DOI:10.1016/S0958-1669(00)00140-3