Cardioacceleratory effects of Manduca sexta allatotropin in the true armyworm moth, Pseudaletia unipuncta

• Published in: Peptides (New York, N.Y. : 1980) Vol. 23; no. 4; pp. 645 - 651
• Main Authors: Koladich, P.M., Cusson, M., Bendena, W.G., Tobe, S.S., McNeil, J.N.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.04.2002
• Subjects: Allatostatin; Allatotropin; Animals; Cardioacceleratory peptide; Corpora Allata - drug effects; Dose-Response Relationship, Drug; Female; Heart - drug effects; Heart - physiology; In Vitro Techniques; Insect heart; Insect Hormones - pharmacology; Juvenile hormone; Juvenile Hormones - biosynthesis; Male; Manduca - chemistry; Manduca sexta; Moths - anatomy & histology; Moths - metabolism; Neuropeptides - pharmacology; Noctuidae; Pseudaletia unipuncta; Serotonin; Serotonin - pharmacology; Serotonin; Cardioacceleratory peptide; Allatotropin; Manduca sexta; Insect heart; Pseudaletia unipuncta; Allatostatin; Juvenile hormone
• ISSN: 0196-9781; 1873-5169
• DOI: 10.1016/S0196-9781(01)00658-1

Manduca sexta allatotropin (Manse-AT), a peptide originally isolated on the basis of its ability to stimulate juvenile hormone (JH) biosynthesis in the tobacco hornworm, is a potent in vitro stimulator of the corpora allata (CA) in Pseudaletia unipuncta (Lepidoptera: Noctuidae). At 10 −6M, Manse-AT stimulated in vitro rates of JH biosynthesis by CA of day 0 and 6 adult females 15- and 10-fold respectively. Both Manse-AT and serotonin were also shown to be dose-dependent stimulators of heart rate in day 0, 3 and 6 adult males and females. Furthermore, analysis suggests that there are differences in both resting and Manse-AT-stimulated heart rates depending on age and rearing conditions.