Microwave-assisted one-pot syntheses of 4-aminoquinazolines

A simple, environmentally friendly, one-pot method for the synthesis of 4-aminoquinazolines using microwave irradiation has been developed. Structures of derivatives , , and were confirmed by single-crystal X-ray diffraction. The cytotoxicity of each compound was investigated using an MTT assay with...

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Bibliographic Details
Published inGreen processing and synthesis Vol. 5; no. 3; pp. 247 - 252
Main Authors Song, Wenting, He, Shunli, Yuan, Zeli, Yu, Guangqing, Wu, Di, Wu, Qing, Zhang, Minqing, Chen, Yongzheng, Hu, Qinghong
Format Journal Article
LanguageEnglish
Published Berlin De Gruyter 01.06.2016
Walter de Gruyter GmbH
Subjects
4-aminoquinazoline
Cytotoxicity
Irradiation
methodology
microwave assisted
one-pot syntheses
X-ray diffraction
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Summary:A simple, environmentally friendly, one-pot method for the synthesis of 4-aminoquinazolines using microwave irradiation has been developed. Structures of derivatives , , and were confirmed by single-crystal X-ray diffraction. The cytotoxicity of each compound was investigated using an MTT assay with A549 and HepG2 cell lines to calculate half-maximal inhibitory concentrations.
ISSN:2191-9542
2191-9550
DOI:10.1515/gps-2015-0121