Microwave-assisted one-pot syntheses of 4-aminoquinazolines
A simple, environmentally friendly, one-pot method for the synthesis of 4-aminoquinazolines using microwave irradiation has been developed. Structures of derivatives , , and were confirmed by single-crystal X-ray diffraction. The cytotoxicity of each compound was investigated using an MTT assay with...
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Published in | Green processing and synthesis Vol. 5; no. 3; pp. 247 - 252 |
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Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Berlin
De Gruyter
01.06.2016
Walter de Gruyter GmbH |
Subjects | |
Online Access | Get full text |
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Summary: | A simple, environmentally friendly, one-pot method for the synthesis of 4-aminoquinazolines using microwave irradiation has been developed. Structures of derivatives
,
, and
were confirmed by single-crystal X-ray diffraction. The
cytotoxicity of each compound was investigated using an MTT assay with A549 and HepG2 cell lines to calculate half-maximal inhibitory concentrations. |
---|---|
ISSN: | 2191-9542 2191-9550 |
DOI: | 10.1515/gps-2015-0121 |