Effect of pregnancy and tobacco smoke on the antioxidant activity of rutin in an animal model

• Published in: Pharmacological reports Vol. 61; no. 5; pp. 935 - 940
• Main Authors: Florek, Ewa, Ignatowicz, Ewa, Piekoszewski, Wojciech
• Format: Journal Article
• Language: English
• Published: Cham Elsevier Urban & Partner Sp. z o.o 01.09.2009; Springer International Publishing
• Subjects: Animals; Antioxidants - metabolism; Brain - drug effects; Brain - metabolism; Drug Safety and Pharmacovigilance; Female; Kidney - drug effects; Kidney - metabolism; Liver - drug effects; Liver - metabolism; Lung - drug effects; Lung - metabolism; Oxidative Stress - drug effects; Pharmacotherapy; Pharmacy; Pregnancy; pregnant rat; Rats; Rats, Wistar; rutin; Rutin - pharmacology; Short Communication; tobacco smoke; Tobacco Smoke Pollution - adverse effects; total antioxidant status; tobacco smoke; rutin; pregnant rat; total antioxidant status
• ISSN: 1734-1140; 2299-5684
• DOI: 10.1016/S1734-1140(09)70152-5

Tobacco smoke is a source of free radicals and causes oxidative stress in smokers’ tissues. The aim of the current study was to evaluate the effect of rutin on the total antioxidant status (TAS) in pregnant and non-pregnant rats that were exposed to cigarette smoke. TAS in brain, lungs, liver, kidneys and plasma were measured by the 2,2’-azinobis(3-ethylbenzothiazoline-6-sulfonate) (ABTS) radicalcation decolorization assay. In pregnant rats, a diversified distribution of endogenous antioxidants was found in comparison to the matched non-pregnant animals. In pregnant rats, TAS was higher in plasma (by 33%) and kidney (by 76%), and lower in brain (by 48%) and liver (by 50%) compared with non-pregnant rats. Generally (except liver), exposure to tobacco smoke caused an increase in the antioxidative status of pregnant compared to non-pregnant animals (by 29, 16, 18 and 87% in plasma, brain, lung and kidney, respectively). Overall, rutin had little (plasma, non-pregnant rats) or a no protective effect in the examined tissues.