Polysaccharide from Salviae miltiorrhizae Radix et Rhizoma Attenuates the Progress of Obesity-Induced Non-Alcoholic Fatty Liver Disease through Modulating Intestinal Microbiota-Related Gut–Liver Axis

• Published in: International journal of molecular sciences Vol. 23; no. 18; p. 10620
• Main Authors: Li, Lixia, Lan, Xinting, Peng, Xi, Shi, Shuai, Zhao, Yanlin, Liu, Wentao, Luo, Qihui, Jia, Lanlan, Feng, Bin, Chen, Zhengli, Zou, Yuanfeng, Huang, Chao
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 13.09.2022; MDPI
• Subjects: Anion exchanging; Crohns disease; Digestive system; Ethanol; Fatty liver; Fibrosis; Gel filtration; Gene expression; gut microbiota; gut–liver axis; High fat diet; Homeostasis; Inflammatory bowel disease; Intestinal microflora; Intestine; Liver; Liver diseases; Microbiota; NAFLD; Obesity; Permeability; polysaccharide; Polysaccharides; Salviae miltiorrhizae Radix et Rhizoma; Small intestine; Steatosis; Water purification
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms231810620

Non-alcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease worldwide, thus treatments for it have attracted lots of interest. In this study, the Salviae miltiorrhizae Radix et Rhizoma (SMRR) polysaccharide was isolated by hot water extraction and ethanol precipitation, and then purified by DEAE anion exchange chromatography and gel filtration. With a high-fat-diet-induced obesity/NAFLD mouse model, we found that consumption of the SMRR polysaccharide could remarkably reverse obesity and its related progress of NAFLD, including attenuated hepatocellular steatosis, hepatic fibrosis and inflammation. In addition, we also reveal the potential mechanism behind these is that the SMRR polysaccharide could regulate the gut–liver axis by modulating the homeostasis of gut microbiota and thereby improving intestinal function.