Chiral Amine Synthesis - Recent Developments and Trends for Enamide Reduction, Reductive Amination, and Imine Reduction

The review examines the chiral amine literature from 2000–2009 (May) concerning enantioselective and diastereoselective methods for N‐acylenamide and enamine reduction, reductive amination, and imine reduction. The reaction steps for each strategy, from ketone to primary chiral amine, are clearly de...

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Bibliographic Details
Published inAdvanced synthesis & catalysis Vol. 352; no. 5; pp. 753 - 819
Main Authors Nugent, Thomas C., El-Shazly, Mohamed
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag 22.03.2010
WILEY‐VCH Verlag
Subjects
Amines
Amino acids
asymmetric reduction
Categories
chiral amines
enamide reduction
enantioselective reduction
imine reduction
Imines
Readers
Reduction
reductive amination
Strategy
Synthesis
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Summary:The review examines the chiral amine literature from 2000–2009 (May) concerning enantioselective and diastereoselective methods for N‐acylenamide and enamine reduction, reductive amination, and imine reduction. The reaction steps for each strategy, from ketone to primary chiral amine, are clearly defined, with best methods and yields for starting material preparation and final deprotection noted. Categories of chiral amines have been defined in Section 1 to allow the reader to quickly understand whether their specific target amine falls within a difficult to synthesize, or not, structural class. Amino acids are not considered in this work.
Bibliography:ArticleID:ADSC200900719
ark:/67375/WNG-TZGKQTLD-7
Jacobs University Bremen
istex:713743E8F344C2F923C49172F0103315F31D5983
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SourceType-Scholarly Journals-1
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ISSN:1615-4150
1615-4169
1615-4169
DOI:10.1002/adsc.200900719