Unchanged rat brain amyloid precursor protein levels after exposure to benzodiazepines in vivo

• Published in: European journal of anaesthesiology Vol. 23; no. 9; p. 772
• Main Authors: Kálmán, J, Palotás, M, Pákáski, M, Hugyecz, M, Janka, Z, Palotás, A
• Format: Journal Article
• Language: English
• Published: England 01.09.2006
• Subjects: Alzheimer Disease - metabolism; Alzheimer Disease - pathology; Amyloid beta-Peptides - biosynthesis; Anesthesia, General; Animals; Antibodies, Monoclonal - chemistry; Benzodiazepines - metabolism; Benzodiazepines - toxicity; Brain - metabolism; Diazepam - pharmacology; Male; Midazolam - pharmacology; Postoperative Period; Rats; Rats, Sprague-Dawley; Risk

Recent studies emphasize a positive correlation between (cardiac) surgical interventions and increased risk for developing Alzheimer's disease in the late postoperative period. Since amyloid precursor protein and its neurotoxic derivatives play key roles in the development of Alzheimer's d...