Unchanged rat brain amyloid precursor protein levels after exposure to benzodiazepines in vivo

Recent studies emphasize a positive correlation between (cardiac) surgical interventions and increased risk for developing Alzheimer's disease in the late postoperative period. Since amyloid precursor protein and its neurotoxic derivatives play key roles in the development of Alzheimer's d...

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Bibliographic Details
Published inEuropean journal of anaesthesiology Vol. 23; no. 9; p. 772
Main Authors Kálmán, J, Palotás, M, Pákáski, M, Hugyecz, M, Janka, Z, Palotás, A
Format Journal Article
LanguageEnglish
Published England 01.09.2006
Subjects
Alzheimer Disease - metabolism
Alzheimer Disease - pathology
Amyloid beta-Peptides - biosynthesis
Anesthesia, General
Animals
Antibodies, Monoclonal - chemistry
Benzodiazepines - metabolism
Benzodiazepines - toxicity
Brain - metabolism
Diazepam - pharmacology
Male
Midazolam - pharmacology
Postoperative Period
Rats
Rats, Sprague-Dawley
Risk
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Summary:Recent studies emphasize a positive correlation between (cardiac) surgical interventions and increased risk for developing Alzheimer's disease in the late postoperative period. Since amyloid precursor protein and its neurotoxic derivatives play key roles in the development of Alzheimer's dementia, the impact of several agents used in the intra- and perioperative period is examined. Amyloid precursor protein concentrations were assessed by semi-quantitative Western-immunoblot in brains of rats following intraperitoneal treatment with diazepam and midazolam. There were no significant changes in the amyloid precursor protein concentrations. Both diazepam and midazolam are considered to be relatively safe with respect to amyloid precursor protein metabolism.
ISSN:0265-0215
DOI:10.1017/S0265021506000494