Kallmann's syndrome: is it always for life?

• Published in: Clinical endocrinology (Oxford) Vol. 50; no. 4; pp. 481 - 485
• Main Authors: QUINTON, R, CHEOW, H. K, TYMMS, D. J, BOULOUX, P.-M. G, WU, F. C. W, JACOBS, H. S
• Format: Journal Article
• Language: English
• Published: Oxford BSL Blackwell Science Ltd 01.04.1999; Blackwell; Wiley Subscription Services, Inc
• Subjects: Adolescent; Adult; Biological and medical sciences; Diabetes. Impaired glucose tolerance; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Follow-Up Studies; Gonadotropins, Pituitary - blood; Gonadotropins, Pituitary - metabolism; Humans; Kallmann Syndrome - physiopathology; Male; Medical sciences; Remission, Spontaneous; Testis - physiopathology; Endocrinopathy; Human; Hypogonadotropic hypogonadism; Nervous system diseases; Prognosis; Hypothalamic diseases; Clinical form; Kallmann syndrome; Cerebral disorder; Case study; Malformation; Follow up study; Central nervous system disease; ENT disease
• ISSN: 0300-0664; 1365-2265
• DOI: 10.1046/j.1365-2265.1999.00708.x

OBJECTIVE Kallmann's syndrome (KS) is defined by the association of olfactory deficit with irreversible, congenital gonadotrophin deficiency (IHH). We present evidence for the existence of a variant form of KS, in which endogenous gonadotrophin secretion recovers spontaneously in later life. DESIGN Longitudinal clinical study. PATIENTS Five men with anosmia or severe hyposmia, who originally presented in their late teens or early twenties as a result of severe pubertal delay and were thus presumed to have KS. RESULTS Spontaneous onset of endogenous gonadotrophin secretion, evidenced by progressive normalization of testicular volume and of serum testosterone concentration, occurred in these men over a period of years following the initial diagnosis. CONCLUSIONS This variant form of Kallman's syndrome is not well recognized and may well be under‐diagnosed. Once full virilization has been induced, males with congenital gonadotrophin deficiency whose testes have significantly increased in size should be reassessed, off androgen replacement therapy, to identify those who no longer require treatment.