An early diagnostic tool for diabetic neuropathy: Conduction velocity distribution

• Published in: Muscle & nerve Vol. 43; no. 2; pp. 237 - 244
• Main Authors: Tuncer, Seckin, Dalkilic, Nizamettin, Esen, Haci Hasan, Avunduk, Mustafa Cihat
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.02.2011; Wiley
• Subjects: Action Potentials - drug effects; Action Potentials - physiology; Analysis of Variance; Animals; Biological and medical sciences; Biophysics - methods; Blood Glucose - physiology; Body Weight - drug effects; compound action potential; Cranial nerves. Spinal roots. Peripheral nerves. Autonomic nervous system. Gustation. Olfaction; Diabetes. Impaired glucose tolerance; Diabetic Neuropathies - chemically induced; Diabetic Neuropathies - diagnosis; Diabetic Neuropathies - pathology; diabetic peripheral neuropathy; Disease Models, Animal; Electric Stimulation - methods; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Male; Mathematical Computing; Medical sciences; Motor Neurons - pathology; nerve conduction velocity distribution; Nervous system (semeiology, syndromes); Neural Conduction - physiology; Neurology; rat; Rats; Rats, Sprague-Dawley; Reaction Time - physiology; sciatic nerve; Sciatic Nerve - drug effects; Sciatic Nerve - physiopathology; Streptozocin - toxicity; Time Factors; Endocrinopathy; Peripheral nerve; diabetic peripheral neuropathy; compound action potential; Rat; Measurement result; Electrophysiology; Action potential; Velocity distribution; Neuropathy; Conduction velocity; Nerve conduction; Computer; Diagnosis; Peripheral nerve disease; Mathematical model; Human; Nervous system diseases; Diabetes mellitus; Rodentia; nerve conduction velocity distribution; Vertebrata; Metabolic disorder; Mammalia; Sciatic nerve
• ISSN: 0148-639X; 1097-4598
• DOI: 10.1002/mus.21837

Diabetes is a metabolic disorder that affects much of the human population. As a secondary complication, diabetic neuropathy causes time‐dependent damage to peripheral nerves. In this study, experimental diabetes was induced by streptozotocin (STZ; 50 mg/kg intraperitoneally) in rats. Diabetic animals were grouped into those with 2 or 4 weeks of diabetes, whereas a control group received only the STZ vehicle (0.1 M citrate). Sciatic nerves were dissected, and compound action potentials (CAPs) were recorded. Results deduced by conventional calculation carried less information when compared with conduction velocity distribution (CVD) obtained by a computer‐based mathematical model. Using the conventional approach, statistically significant changes were first seen in the fourth week of diabetes, whereas results deduced by CVD measurement could be seen in the second week. Consequently, the CVD calculation provides more information for the early diagnosis of neuropathies compared with classical conduction velocity measurements. Muscle Nerve 43: 237–244, 2011