Anemia in young patients with ischaemic stroke
Background and purpose To investigate the association of anemia on admission with ischaemic stroke (IS), stroke severity and early functional outcome in patients with cervical artery dissection (CeAD) or with IS of other causes (non‐CeAD‐IS patients). Methods The study sample comprised all patients...
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Published in | European journal of neurology Vol. 22; no. 6; pp. 948 - 953 |
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Main Authors | , , , , , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
England
Blackwell Publishing Ltd
01.06.2015
John Wiley & Sons, Inc Wiley |
Subjects | |
Online Access | Get full text |
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Summary: | Background and purpose
To investigate the association of anemia on admission with ischaemic stroke (IS), stroke severity and early functional outcome in patients with cervical artery dissection (CeAD) or with IS of other causes (non‐CeAD‐IS patients).
Methods
The study sample comprised all patients from the Cervical Artery Dissection and Ischaemic Stroke Patients (CADISP) study without pre‐existing disability and with documentation of stroke severity and hemoglobin (Hb) concentration on admission. Anemia was classified as mild (Hb < 12 g/dl in women and Hb < 13 g/dl in men) or moderate to severe (Hb < 10 g/dl in women and Hb < 11 g/dl in men). Stroke severity on admission was assessed with the National Institutes of Health Stroke Scale (NIHSS). Outcome after 3 months was assessed with the modified Rankin Scale (mRS‐3mo). Unfavorable outcome was defined as mRS‐3mo ≥ 3.
Results
Amongst 1206 study patients (691 CeAD and 515 non‐CeAD), 87 (7.2%) had anemia, which was moderate to severe in 18 (1.5%) patients. Anemia was associated with female sex in both study samples, but no further associations with risk factors or comorbidities were observed. In CeAD patients, anemia was associated with occurrence of stroke (P = 0.042). In both study samples, anemic patients had more severe strokes (CeAD, P = 0.023; non‐CeAD, P = 0.005). Functional outcome was not associated with anemia in general, but moderate to severe anemia was significantly associated with unfavorable outcome (P = 0.004).
Conclusion
Anemia on admission was associated with stroke in CeAD patients and with more severe strokes in both study samples. Moderate to severe anemia may predict unfavorable outcome. |
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Bibliography: | Paavo Ilmari Ahvenainen Foundation Käthe-Zingg-Schwichtenberg-Fonds of the Swiss Academy of Medical Sciences Maire Taponen Foundation Orion Farmos Research Foundation Finnish Brain Foundation Finnish Medical Foundation Lilly Foundation Academy of Finland Helsinki University Medical Foundation Centre National de Genotypage Aarne and Aili Turunen Foundation Aarne Koskelo Foundation Génopôle de Lille Helsinki University Central Hospital Research Fund Projet Hospitalier de Recherche Clinique Regional ArticleID:ENE12687 Alfred Kordelin Foundation Emil Aaltonen Foundation Päivikki and Sakari Sohlberg Foundation Contrat de Projet Etat − Region 2007 Biomedicum Helsinki Foundation Basel Stroke-Funds Swiss Heart Foundation ark:/67375/WNG-QW54GZ6Q-W Maud Kuistila Foundation Swiss National Science Foundation - No. 33CM30-124119; No. 33CM30-140340/1 Fondation de France istex:41B1EA81D31C2AC3C92708349D713B63153F6C40 Institut Pasteur de Lille ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1351-5101 1468-1331 |
DOI: | 10.1111/ene.12687 |