Preemptive analgesia by lornoxicam--an NSAID--significantly inhibits perioperative platelet aggregation
To investigate whether preemptive administered lornoxicam changes perioperative platelet function during thoracic surgery. A total of 20 patients scheduled for elective thoracic surgery were randomly assigned to receive either lornoxicam (16 mg, i.v.; n = 10) or placebo (n = 10) preoperatively. All...
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Published in | European journal of anaesthesiology Vol. 25; no. 9; p. 726 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
England
01.09.2008
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Subjects | |
Online Access | Get more information |
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Summary: | To investigate whether preemptive administered lornoxicam changes perioperative platelet function during thoracic surgery.
A total of 20 patients scheduled for elective thoracic surgery were randomly assigned to receive either lornoxicam (16 mg, i.v.; n = 10) or placebo (n = 10) preoperatively. All patients underwent treatment of solitary lung metastasis and denied any antiplatelet medication within the past 2 weeks. Blood samples were drawn via an arterial catheter directly into silicone-coated Vacutainer tubes containing 0.5 mL of 0.129 M buffered sodium citrate 3.8% before, 15 min, 4 h and 8 h after the study medication was administered. Platelet aggregation curves were obtained by whole blood electrical impedance aggregometry (Chrono Log).
Platelet aggregation was significantly reduced 15 min, 4 h and 8 h after lornoxicam administration compared to placebo (P < 0.05) for collagen, adenosine diphosphate and arachidonic acid as trigger substances. Adenosine diphosphate-induced platelet aggregation decreased by 85% 15 min after lornoxicam administration, and remained impaired for 8 h.
Platelet aggregation assays are impaired for at least 8 h after lornoxicam application. Therefore perioperative analgesia by use of lornoxicam should be carefully administered under consideration of subsequent platelet dysfunction. |
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ISSN: | 1365-2346 |
DOI: | 10.1017/S0265021508004274 |