Comparative effects of nebivolol and metoprolol on oxidative stress, insulin resistance, plasma adiponectin and soluble P-selectin levels in hypertensive patients

• Published in: Journal of hypertension Vol. 24; no. 3; p. 591
• Main Authors: Celik, Turgay, Iyisoy, Atila, Kursaklioglu, Hurkan, Kardesoglu, Ejder, Kilic, Selim, Turhan, Hasan, Yilmaz, M Ilker, Ozcan, Omer, Yaman, Halil, Isik, Ersoy, Fici, Francesco
• Format: Journal Article
• Language: English
• Published: England 01.03.2006
• Subjects: Adiponectin - blood; Adult; Antihypertensive Agents - pharmacology; Antihypertensive Agents - therapeutic use; Benzopyrans - pharmacology; Benzopyrans - therapeutic use; Ethanolamines - pharmacology; Ethanolamines - therapeutic use; Female; Humans; Hypertension - blood; Hypertension - drug therapy; Insulin Resistance; Male; Metoprolol - pharmacology; Metoprolol - therapeutic use; Middle Aged; Nebivolol; Oxidative Stress - drug effects; P-Selectin - blood; P-Selectin - drug effects; Prospective Studies; Single-Blind Method
• ISSN: 0263-6352
• DOI: 10.1097/01.hjh.0000209993.26057.de

To determine the effects of nebivolol on oxidative stress, insulin resistance, adiponectin and plasma soluble P-selectin levels in hypertensive patients in comparison with metoprolol. Eighty newly diagnosed hypertensive patients in grade 1 hypertension according to the European Society of Hypertension and European Society of Cardiology guidelines were enrolled in this prospective, blinded, randomized study. Seventy-two patients completed the study. After baseline assessment, each patient was randomly allocated to a 5 mg daily dose of nebivolol (n = 37, 20 male) or a 100 mg daily dose of metoprolol (n = 35, 18 male) and treated for 6 months. Blood pressure, heart rate, oxidative stress (malonyldialdehyde), homeostasis model assessment: insulin resistance, adiponectin and plasma soluble P-selectin levels were measured before and after treatment. At the end of treatment, nebivolol and metoprolol significantly decreased blood pressure and heart rate, with a more pronounced bradycardic effect of metoprolol. Nebivolol, but not metoprolol, significantly lowered oxidative stress (P = 0.03), the insulin resistance index (P = 0.003) and plasma soluble P-selectin levels (P = 0.008), and increased adiponectin levels (P = 0.04). Nebivolol, in contrast to metoprolol, improved oxidative stress, insulin sensitivity, decreased plasma soluble P-selectin and increased adiponectin levels in hypertensive patients. These beneficial effects of nebivolol may contribute to a reduction in cardiovascular risk in hypertensive patients.