Incidence of pancreatic tumors and tumor precursors in Sprague-Dawley rats after administration of olive oil

• Published in: Annals of the New York Academy of Sciences Vol. 534; p. 604
• Main Authors: Perino, G. (Institute of Oncology "F. Addarii", Bologna, Italy), Conti, B, Ciliberti, A, Maltoni, C
• Format: Journal Article
• Language: English
• Published: United States 1988
• Subjects: ACEITES VEGETALES; Adenocarcinoma - chemically induced; Adenocarcinoma - pathology; Adenoma - chemically induced; Adenoma - pathology; Animals; CARCINOMA; CARCINOME; DIET; DIETA; DIGESTIVE SYSTEM DISEASES; ENFERMEDADES (SISTEMA DIGESTIVO); Female; FOOD HYGIENE; HEAVY METALS; HIGIENE DE LOS ALIMENTOS; HUILE VEGETALE; HYGIENE DES ALIMENTS; MALADIE DE L'APPAREIL DIGESTIF; Male; METAL LOURD; METALES PESADOS; NEOPLASMAS; NEOPLASME; NEOPLASMS; OLEA EUROPAEA; Olive Oil; PANCREAS; Pancreas - drug effects; Pancreas - pathology; Pancreatic Neoplasms - chemically induced; Pancreatic Neoplasms - pathology; PESTICIDE; PESTICIDES; PLAGUICIDAS; PLANT OILS; Plant Oils - toxicity; Precancerous Conditions - chemically induced; Precancerous Conditions - pathology; RAT; RATA; RATS; Rats, Inbred Strains; REGIME ALIMENTAIRE; TOXINAS; TOXINE; TOXINS
• ISSN: 0077-8923; 1749-6632
• DOI: 10.1111/j.1749-6632.1988.tb30151.x

We studied the pancreata of 280 (140 males and 140 females) olive-oil-treated and 240 (120 males and 120 females) untreated Sprague-Dawley rats of the breed used at the BT Experimental Unit of the Bologna Institute of Oncology. Extra-virgin olive oil was administered by stomach tube, once daily, for 4-5 days weekly, for 2 years. The animals were kept under observation for as long as 130 weeks. Only a borderline increase in acinar cell adenomas and adenocarcinomas was observed. We found no increase in endocrine oncologic lesions.