Monochorionic twin fetus with VACTERL association after intracytoplasmic sperm injection

• Published in: Congenital anomalies Vol. 53; no. 2; pp. 95 - 97
• Main Authors: Kanasugi, Tomonobu, Kikuchi, Akihiko, Matsumoto, Atsushi, Terata, Miyuki, Isurugi, Chizuko, Oyama, Rie, Fukushima, Akimune, Sugiyama, Toru
• Format: Journal Article
• Language: English
• Published: Melbourne, Australia Blackwell Publishing Asia 01.06.2013; Wiley Subscription Services, Inc
• Subjects: Adult; Anal Canal - abnormalities; Anal Canal - diagnostic imaging; Anal Canal - pathology; Chorion - abnormalities; Chorion - diagnostic imaging; Duodenal Obstruction - diagnostic imaging; Duodenal Obstruction - pathology; Esophagus - abnormalities; Esophagus - diagnostic imaging; Esophagus - pathology; Female; fetal ultrasound; Fetus - abnormalities; Fetuses; Heart Defects, Congenital - diagnostic imaging; Heart Defects, Congenital - pathology; Humans; intracytoplasmic sperm injection; Kidney - abnormalities; Kidney - diagnostic imaging; Kidney - pathology; Limb Deformities, Congenital - diagnostic imaging; Limb Deformities, Congenital - pathology; Male; monochorionic twin; Pregnancy; Prenatal Diagnosis; Sperm; Sperm Injections, Intracytoplasmic - methods; Spine - abnormalities; Spine - diagnostic imaging; Spine - pathology; Trachea - abnormalities; Trachea - diagnostic imaging; Trachea - pathology; Twins; Ultrasonography, Prenatal; VACTERL association
• ISSN: 0914-3505; 1741-4520
• DOI: 10.1111/j.1741-4520.2012.00373.x

ABSTRACT We report a rare case of a monochorionic twin gestation after intracytoplasmic sperm injection (ICSI) in which one of the fetuses had VACTERL association. A 27‐year‐old woman became pregnant by ICSI and was found to have monochorionic twin fetuses. One fetus was noted to have the following anomalies: a multicystic, dysplastic left kidney with a hydroureter, and a dilated colon. A normal‐sized stomach and normal amount of amniotic fluid were observed during the prenatal period with no other anomalies. The postnatal examination revealed hypospadias, and anal, esophageal, and duodenal atresia; thus, a diagnosis of VACTERL association was established. Although the prenatal diagnosis of this disorder is a challenge, even in a singleton, some of the characteristic features observed during antepartum ultrasonography may be a clue to the diagnosis, especially in a twin pregnancy after ICSI.