Clinical outcome of 36 male patients with primary urethral carcinoma: A single center experience

• Published in: International journal of urology Vol. 13; no. 6; pp. 716 - 720
• Main Authors: THYAVIHALLY, YUVARAJA B, TONGAONKAR, HEMANT B, SRIVASTAVA, SHYAM K, MAHANTSHETTY, UMESH, KUMAR, PRABHASH, RAIBHATTANAVAR, SRINIVAS G
• Format: Journal Article
• Language: English
• Published: Melbourne, Australia Blackwell Publishing Asia 01.06.2006
• Subjects: Aged; carcinoma; Carcinoma - mortality; Carcinoma - therapy; Disease-Free Survival; Humans; Male; Middle Aged; Neoplasm Staging; radiotherapy; Retrospective Studies; squamous cell; surgery; Survival Rate; urethra; Urethral Neoplasms - mortality; Urethral Neoplasms - therapy
• ISSN: 0919-8172; 1442-2042
• DOI: 10.1111/j.1442-2042.2006.01392.x

Aim:  Retrospective analysis of male urethral carcinoma to assess the best therapeutic approach to the management of this tumor. Methods:  A review of 36 cases of male urethral carcinoma diagnosed and treated at our center was performed. Clinical features, treatment modality and outcomes were analysed. Results:  The overall median survival time was 55.16 months. The 5‐year overall and disease‐free survival rate for the cohort was 49% and 23%, respectively. The 5‐year survival is 67% for low‐stage versus 33% for high‐stage tumors and is significantly different (P = 0.001). The survival was 72% for tumors of the distal urethra versus 36% for tumors of the proximal, with a P‐value of 0.02. Conclusion:  The tumor location and clinicopathological stage were the most important predictors of the disease‐free and overall survival. Multimodal approach is necessary for achieving local control especially for proximal and higher stage tumors.