Synthesis of Acyclic Selenonucleoside Phosphonates as Potential Antiviral Agents

On the basis of potent antiviral activity of adefovir (1) and tenofovir (2), which are representative acyclic nucleoside phosphonates, bioisosteric acyclic selenonucleoside phosphonates seleno-adefovir (3) and seleno-tenofovir (4) were designed and synthesized from diethyl(iodomethyl)phosphonate (7)...

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Published inAsian journal of organic chemistry Vol. 5; no. 2; pp. 183 - 186
Main Authors Sahu, Pramod K., Kim, Gyudong, Nayak, Akshata, Ahn, Ji Yoon, Ha, Min Woo, Park, Cheonhyoung, Yu, Jinha, Park, Hyeung-geun, Jeong, Lak Shin
Format Journal Article
LanguageEnglish
Published WEINHEIM Wiley 01.02.2016
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
antivirals
NUCLEOTIDE ANALOGS
INFECTIONS
diselenides
MECHANISM
HIV
selenotenofovir
selenoadefovir
HEPATITIS-B
acyclic nucleoside phosphonates
DERIVATIVES
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Abstract On the basis of potent antiviral activity of adefovir (1) and tenofovir (2), which are representative acyclic nucleoside phosphonates, bioisosteric acyclic selenonucleoside phosphonates seleno-adefovir (3) and seleno-tenofovir (4) were designed and synthesized from diethyl(iodomethyl)phosphonate (7) by using diselenide chemistry.
AbstractList On the basis of potent antiviral activity of adefovir (1) and tenofovir (2), which are representative acyclic nucleoside phosphonates, bioisosteric acyclic selenonucleoside phosphonates seleno-adefovir (3) and seleno-tenofovir (4) were designed and synthesized from diethyl(iodomethyl)phosphonate (7) by using diselenide chemistry.
Author Park, Cheonhyoung
Sahu, Pramod K.
Ha, Min Woo
Park, Hyeung-geun
Nayak, Akshata
Ahn, Ji Yoon
Jeong, Lak Shin
Yu, Jinha
Kim, Gyudong
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Cites_doi 10.1016/j.bcp.2006.09.014
10.1021/ic700888w
10.1016/j.tetlet.2013.01.071
10.1134/S1070363208040166
10.1021/acs.jmedchem.5b00804
10.1002/med.21283
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Issue 2
Keywords antivirals
NUCLEOTIDE ANALOGS
INFECTIONS
diselenides
MECHANISM
HIV
selenotenofovir
selenoadefovir
HEPATITIS-B
acyclic nucleoside phosphonates
DERIVATIVES
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PublicationTitle Asian journal of organic chemistry
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Snippet On the basis of potent antiviral activity of adefovir (1) and tenofovir (2), which are representative acyclic nucleoside phosphonates, bioisosteric acyclic...
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Chemistry, Organic
Physical Sciences
Science & Technology
Title Synthesis of Acyclic Selenonucleoside Phosphonates as Potential Antiviral Agents
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