Synthesis of Acyclic Selenonucleoside Phosphonates as Potential Antiviral Agents

On the basis of potent antiviral activity of adefovir (1) and tenofovir (2), which are representative acyclic nucleoside phosphonates, bioisosteric acyclic selenonucleoside phosphonates seleno-adefovir (3) and seleno-tenofovir (4) were designed and synthesized from diethyl(iodomethyl)phosphonate (7)...

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Published inAsian journal of organic chemistry Vol. 5; no. 2; pp. 183 - 186
Main Authors Sahu, Pramod K., Kim, Gyudong, Nayak, Akshata, Ahn, Ji Yoon, Ha, Min Woo, Park, Cheonhyoung, Yu, Jinha, Park, Hyeung-geun, Jeong, Lak Shin
Format Journal Article
LanguageEnglish
Published WEINHEIM Wiley 01.02.2016
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
antivirals
NUCLEOTIDE ANALOGS
INFECTIONS
diselenides
MECHANISM
HIV
selenotenofovir
selenoadefovir
HEPATITIS-B
acyclic nucleoside phosphonates
DERIVATIVES
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Summary:On the basis of potent antiviral activity of adefovir (1) and tenofovir (2), which are representative acyclic nucleoside phosphonates, bioisosteric acyclic selenonucleoside phosphonates seleno-adefovir (3) and seleno-tenofovir (4) were designed and synthesized from diethyl(iodomethyl)phosphonate (7) by using diselenide chemistry.
ISSN:2193-5807
2193-5815
DOI:10.1002/ajoc.201500421