Management of sickle cell disease: current practices and challenges in a northeastern region of the Democratic Republic of the Congo

• Published in: Hematology (Luxembourg) Vol. 26; no. 1; pp. 199 - 205
• Main Authors: Kambale-Kombi, Paul, Marini Djang'eing'a, Roland, Alworong'a Opara, Jean-Pierre, Minon, Jean-Marc, Boemer, François, Bours, Vincent, Tonen-Wolyec, Serge, Kayembe Tshilumba, Charles, Batina-Agasa, Salomon
• Format: Journal Article Web Resource
• Language: English
• Published: England Taylor & Francis 01.01.2021; Taylor and Francis
• Subjects: challenges; current practices; Democratic Republic of the Congo; Hematology; Human health sciences; hydroxyurea; Hématologie; immunization; malaria chemoprophylaxis; management; Penicillin prophylaxis; Sciences de la santé humaine; Sickle cell disease; current practices; hydroxyurea; challenges; management; immunization; Penicillin prophylaxis; malaria chemoprophylaxis; Democratic Republic of the Congo; Sickle cell disease
• ISSN: 1607-8454; 1024-5332; 1607-8454
• DOI: 10.1080/16078454.2021.1880752

The Democratic Republic of the Congo (DRC) is the third most affected country worldwide by sickle cell disease (SCD). However, this disease is still orphaned in the country; large-scale control actions are rare, and little is known about its management. To assess current practices in the management of SCD in Kisangani, DRC. This cross-sectional study was conducted in six health facilities in Kisangani. It involved 198 presumed sickle cell patients attending the above health facilities. The study focused on the sociodemographic and clinical data of the participants, obtained through a clinical examination and their medical records. Diagnostic confirmation of SCD was made by high-performance liquid chromatography coupled to mass spectrometry. Data were analyzed using SPSS 20.0. The diagnosis of SCD was confirmed in 194 (98.0%; 95% CI: 94.9-99.2) participants, while it was not confirmed in 4 (2.0%; 95% CI: 0.8-5.1) participants. The diagnosis was mainly made by the Emmel test (42.9%). 45.8% of participants had previously been transfused with the blood of their parents. Folic acid was taken by 48.5% of participants and the previous intake of hydroxyurea was reported in 5.1% of participants. The participants vaccinated against Pneumococcus were 13.6% and against Haemophilus influenzae type b 28.3%. Penicillin prophylaxis was received by only 1.5% and malaria prophylaxis by 11.6% of participants. Standard-care practices for SCD patients in Kisangani are insufficient. The Congolese government should regard this disease as a health priority and consider actions to improve its management.