Macrophage immunomodulatory activity of extracellular polysaccharide (PEP) of Antarctic bacterium Pseudoaltermonas sp.S-5

• Published in: International immunopharmacology Vol. 12; no. 4; pp. 611 - 617
• Main Authors: Bai, Yungui, Zhang, Pengying, Chen, Guochuang, Cao, Jianfeng, Huang, Taotao, Chen, Kaoshan
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier B.V 01.04.2012; Elsevier
• Subjects: Animals; Antarctic bacteria; Biological and medical sciences; Cell Survival - drug effects; Cells, Cultured; Immunologic Factors - pharmacology; Immunomodulator; Interleukin-1beta - immunology; Macrophages; Macrophages, Peritoneal - drug effects; Macrophages, Peritoneal - immunology; Medical sciences; Mice; Nitric Oxide - immunology; Phagocytosis - drug effects; Pharmacology. Drug treatments; Polysaccharide; Polysaccharides, Bacterial - pharmacology; Pseudoaltermonas sp.S-5; Pseudoalteromonas; Superoxides - immunology; Tumor Necrosis Factor-alpha - immunology; Immunomodulator; Macrophages; Polysaccharide; Antarctic bacteria; Pseudoaltermonas sp.S-5; Immunomodulation; Bacteria; Extracellular; Biological activity; Macrophage

Antarctic bacteria are a novel source of polysaccharides which might have potential applications as biological response modifiers (BRM). A heteropolysaccharide (PEP) was isolated from the liquid culture broth of the Antarctic bacterium Pseudoaltermonas sp.S-5. PEP contained Mannose, Glucose, and Gal...