Stimuli-responsive tertiary amine methacrylate-based block copolymers: Synthesis, supramolecular self-assembly and functional applications

• Published in: Progress in polymer science Vol. 39; no. 6; pp. 1096 - 1143
• Main Authors: Hu, Jinming, Zhang, Guoying, Ge, Zhishen, Liu, Shiyong
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 01.06.2014; Elsevier
• Subjects: Applied sciences; Exact sciences and technology; Functional applications; Kinetics; Organic polymers; pH-responsive; Physicochemistry of polymers; Polymers with particular properties; Preparation, kinetics, thermodynamics, mechanism and catalysts; Structural fixation; Supramolecular self-assembly; Tertiary amine-based block copolymers; PP; NFHOK; DVS; HEEDTA; MPC; GTP; PS; PMCL; Pt NPs; Supramolecular self-assembly; MEMA; HAuCl4; P3HT; TPFCBPMA; PSSNa; VBA; PTAN; CMA; nBMA; EGDMA; RAFT; PFS; AIE; MAIpGlc; PISA; AD; AzPMA; PUMVS; PGA; Tertiary amine-based block copolymers; THPMA; MW(s); DPA; PHEGMA; PMEO2MA; Azo; BIEE; cmc; LCST; Kinetics; FOMA; PISR; PDMAEA; PEEP; p-TSCl; UCST; PPO; Au NPs; Functional applications; FITC; tBMA; DHPE; E. coli; HMTETA; PLK1; CEMA; CL; PIC; Structural fixation; 2VP; HEMA; EBiB; pH-responsive; AmB; GPC; PAM; PEGMA; PMAGIc; NaBH4; AzoMA; (P)QA; NIPAM; PAEMA; MTS; PTMS; (M)AA; ImPAA; DHBC(s); CuBr; MAPTAC; TBABB; ATRP; EEP; ROP; cryo-TEM; pDNA; IEP; PMPDSAH; DLA; M(M)A; CuCl; Ea; HPMA; PDMS; LLA; CRP; BPN; QDs; Mn; QDMA; AzoM; PBLG; POEGMA; DLS; PMDETA; GAMA; PSVBP; TDA; DP(s); PDF; PAPMA; Nagg; NHS; DMA; ARGET; DEA; PFOMA; VEGF; Con A; LAMA; bpy; siRNA; CCL; PGMA; PSoMA; PDHMA; SAXS; PB; β-CD; PEG; PF; PI; SCL; DTBP; PET; Review; Mechanism; Monodispersed polymer; Preparation; Molecular aggregation; Methacrylate copolymer; Aqueous solution; Amine copolymer; Medical application; Block copolymer; Amphiphilic polymer
• ISSN: 0079-6700; 1873-1619
• DOI: 10.1016/j.progpolymsci.2013.10.006

In the past decade, responsive polymers exhibiting reversible or irreversible changes in physical properties and/or chemical structures in response to external stimuli have been extensively investigated. Among them, tertiary amine methacrylate-based block copolymers represent a unique category considering their responsiveness to multiple external stimuli (e.g., pH, temperature and salts), which are essentially relevant to the biological milieu. These intriguing properties allow for their applications in a variety of fields ranging from drug or gene delivery, imaging, diagnostics, antibacterial coatings, catalysis, and bio-separations. This review article highlights tertiary amine methacrylate-based block copolymers, focusing on recent advances in the synthesis of tertiary amine methacrylate-based block copolymers with varying chemical structures and chain topologies, their supramolecular self-assembly in aqueous media as well as in the bulk state, and the emerging functional applications.