Dynamic evolution of the CYP2ABFGST gene cluster in primates

• Published in: Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis Vol. 616; no. 1-2; pp. 133 - 138
• Main Authors: Hoffman, Susan M G, Hu, Shengyong
• Format: Journal Article
• Language: English
• Published: Netherlands 01.03.2007
• Subjects: Animals; Aryl Hydrocarbon Hydroxylases - genetics; Chromosome Mapping; Evolution, Molecular; Humans; Macaca mulatta; Multigene Family; Pan troglodytes; Steroid Hydroxylases - genetics

We have annotated and analyzed sequences from the CYP2ABFGST gene cluster for the chimpanzee and the Rhesus macaque, and compared them in detail to the complete map of the syntenic human cluster. While the macaque cluster has accumulated substantial differences in gene number and organization relati...