Dynamic evolution of the CYP2ABFGST gene cluster in primates

We have annotated and analyzed sequences from the CYP2ABFGST gene cluster for the chimpanzee and the Rhesus macaque, and compared them in detail to the complete map of the syntenic human cluster. While the macaque cluster has accumulated substantial differences in gene number and organization relati...

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Bibliographic Details
Published inMutation Research-Fundamental and Molecular Mechanisms of Mutagenesis Vol. 616; no. 1-2; pp. 133 - 138
Main Authors Hoffman, Susan M G, Hu, Shengyong
Format Journal Article
LanguageEnglish
Published Netherlands 01.03.2007
Subjects
Animals
Aryl Hydrocarbon Hydroxylases - genetics
Chromosome Mapping
Evolution, Molecular
Humans
Macaca mulatta
Multigene Family
Pan troglodytes
Steroid Hydroxylases - genetics
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Summary:We have annotated and analyzed sequences from the CYP2ABFGST gene cluster for the chimpanzee and the Rhesus macaque, and compared them in detail to the complete map of the syntenic human cluster. While the macaque cluster has accumulated substantial differences in gene number and organization relative to the other two species, the chimpanzee cluster has remained surprisingly similar to the human cluster, given the evolutionary volatility of this gene family. The comparison will allow us to further refine our model of the evolution of this gene family in mammals.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0027-5107
1386-1964
0027-5107
DOI:10.1016/j.mrfmmm.2006.11.004