Aquagenic Palmar Wrinkling Induced by Combined Use of Salazopyrin and Indomethacin

Aquagenic palmar wrinkling (APW) is an uncommon dermatological condition, which manifests as asymptomatic or tender palmar papules and may cause discomfort and manual functional limitations during its flares. Despite some studies implying a relationship between cystic fibrosis (CF) and APW, there ar...

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Bibliographic Details
Published inCase reports in dermatology Vol. 5; no. 1; pp. 21 - 26
Main Authors Gündüz, Özgür, Özsaraç, KıvılcımÇınkır, Ercin, Mustafa Emre
Format Journal Article
LanguageEnglish
Published Basel, Switzerland S. Karger AG 01.01.2013
Karger Publishers
Subjects
Aquagenic palmar wrinkling
Aquaporin
Cyclooxygenase
Indomethacin
Prostaglandins
Published: January 2013
Salazopyrin
Aquagenic palmar wrinkling
Salazopyrin
Cyclooxygenase
Prostaglandins
Indomethacin
Aquaporin
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Summary:Aquagenic palmar wrinkling (APW) is an uncommon dermatological condition, which manifests as asymptomatic or tender palmar papules and may cause discomfort and manual functional limitations during its flares. Despite some studies implying a relationship between cystic fibrosis (CF) and APW, there are also reports of APW cases without an accompanying CF. In this report we describe a 19-year-old ankylosing spondylitis patient, who developed APW lesions after the start of combined salazopyrin and indomethacin treatment. His palmar lesions were resistant to topical corticosteroid and aluminium hydroxide therapy and disappeared only after stopping the anti-inflammatory drugs. With this report, we aim to highlight and address this underrecognized dermatological condition and possible role of aquaporins in its pathogenesis.
ISSN:1662-6567
1662-6567
DOI:10.1159/000346744