Neuroprotective activity of galloylated cyanogenic glucosides and hydrolysable tannins isolated from leaves of Phyllagathis rotundifolia

• Published in: Fitoterapia Vol. 83; no. 1; pp. 223 - 229
• Main Authors: Tan, Hooi Poay, Wong, Daniel Zin Hua, Ling, Sui Kiong, Chuah, Cheng Hock, Kadir, Habsah Abdul
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 2012; Elsevier
• Subjects: Animals; Biological and medical sciences; Cell Line; Cell Survival - drug effects; Dose-Response Relationship, Drug; Galloylated cyanogenic glucosides; General pharmacology; Glucosides - chemistry; Glucosides - pharmacology; H 2O 2; Hydrogen Peroxide - toxicity; Hydrolysable tannins; Hydrolyzable Tannins - chemistry; Hydrolyzable Tannins - pharmacology; Medical sciences; Mice; Molecular Structure; Neuroprotective; Neuroprotective Agents - pharmacology; NG108-15 hybridoma cell line; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; Phyllagathis rotundifolia; H 2O 2; NG108-15 hybridoma cell line; Neuroprotective; Hydrolysable tannins; Galloylated cyanogenic glucosides; Phyllagathis rotundifolia; Neuroprotection; Hydrogen peroxide; Phenolic acid; Pharmacognosy; Hybridoma; H; Plant leaf; Cyanogenic glucoside; In vitro; Gallic acid derivatives; Medicinal plant; O; NG 108-15 hybridoma cell line; Polyphenol; Tannin; Established cell line; Plant origin; Phenols
• ISSN: 0367-326X; 1873-6971
• DOI: 10.1016/j.fitote.2011.10.019

The galloylated cyanogenic glucosides based on prunasin ( 1– 7), gallotannins ( 8– 14), ellagitannins ( 15– 17), ellagic acid derivatives ( 18, 19) and gallic acid ( 20) isolated from the leaves of Phyllagathis rotundifolia (Melastomataceae) were investigated for their neuroprotective activity against hydrogen peroxide (H 2O 2)-induced oxidative damage in NG108-15 hybridoma cell line. Among these compounds, the gallotannins and ellagitannins exhibited remarkable neuroprotective activities against oxidative damage in vitro as compared to galloylated cyanogenic glucosides and ellagic acid derivatives in a dose-dependent manner. They could be explored further as potential natural neuroprotectors in various remedies of neurodegenerative diseases. Galloylated cyanogenic glucosides, gallotannins and ellagitannins isolated from the leaves of Phyllagathis rotundifolia showed neuroprotective activity. [Display omitted]