Cloning and structural organization of the gene encoding the murine nuclear receptor transcription factor, NURR1
NURR1 is an immediate early gene product and a member of the nuclear receptor superfamily of transcription factors. Using the NURR1 cDNA as a probe, we isolated the genomic DNA encoding NURR1 from a mouse 129SvEv genomic library. The NURR1 gene is approximately 6.2 kb long and is organized into 7 ex...
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| Published in | Gene Vol. 187; no. 1; pp. 135 - 139 |
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| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Netherlands
Elsevier B.V
10.03.1997
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| Abstract | NURR1 is an immediate early gene product and a member of the nuclear receptor superfamily of transcription factors. Using the NURR1 cDNA as a probe, we isolated the genomic DNA encoding NURR1 from a mouse 129SvEv genomic library. The NURR1 gene is approximately 6.2 kb long and is organized into 7 exons separated by 6 introns. Structural analysis of the NURR1 reveals that this gene shares a similar structure with that of the nuclear receptor NUR77/NGF1-B. As in NUR77, the promoter region of NURR1 lacks an identifiable TATA box, but is GC-rich. The proximal promoter region also contains an ATF/CREB consensus binding site that may participate in cAMP-mediated induction of this immediate early gene product. Isolation and structural characterization of the NURR1 gene provides information for further developmental and transcriptional regulation studies of this gene. |
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| AbstractList | NURR1 is an immediate early gene product and a member of the nuclear receptor superfamily of transcription factors. Using the NURR1 cDNA as a probe, we isolated the genomic DNA encoding NURR1 from a mouse 129SvEv genomic library. The NURR1 gene is approximately 6.2 kb long and is organized into 7 exons separated by 6 introns. Structural analysis of the NURR1 reveals that this gene shares a similar structure with that of the nuclear receptor NUR77/NGF1-B. As in NUR77, the promoter region of NURR1 lacks an identifiable TATA box, but is GC-rich. The proximal promoter region also contains an ATF/CREB consensus binding site that may participate in cAMP-mediated induction of this immediate early gene product. Isolation and structural characterization of the NURR1 gene provides information for further developmental and transcriptional regulation studies of this gene. |
| Author | Conneely, Orla M. Ediger, Tracy R. Saucedo-Cardenas, Odila Kardon, Rachele Lydon, John P. |
| Author_xml | – sequence: 1 givenname: Odila surname: Saucedo-Cardenas fullname: Saucedo-Cardenas, Odila – sequence: 2 givenname: Rachele surname: Kardon fullname: Kardon, Rachele – sequence: 3 givenname: Tracy R. surname: Ediger fullname: Ediger, Tracy R. – sequence: 4 givenname: John P. surname: Lydon fullname: Lydon, John P. – sequence: 5 givenname: Orla M. surname: Conneely fullname: Conneely, Orla M. |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/9073077$$D View this record in MEDLINE/PubMed |
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| SubjectTerms | Activating Transcription Factor 1 Animals Base Sequence Binding Sites Cloning, Molecular Consensus Sequence Cyclic AMP Response Element-Binding Protein - metabolism DNA-Binding Proteins - chemistry DNA-Binding Proteins - genetics Exons - genetics Introns - genetics Mice Molecular Sequence Data Nerve Tissue Proteins - chemistry Nerve Tissue Proteins - genetics Nuclear Receptor Subfamily 4, Group A, Member 1 Nuclear Receptor Subfamily 4, Group A, Member 2 NUR77 Promoter Promoter Regions, Genetic Receptors, Cytoplasmic and Nuclear Receptors, Steroid Transcription Factors - chemistry Transcription Factors - genetics Transcription Factors - metabolism Transcription, Genetic |
| Title | Cloning and structural organization of the gene encoding the murine nuclear receptor transcription factor, NURR1 |
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