Cloning and structural organization of the gene encoding the murine nuclear receptor transcription factor, NURR1

NURR1 is an immediate early gene product and a member of the nuclear receptor superfamily of transcription factors. Using the NURR1 cDNA as a probe, we isolated the genomic DNA encoding NURR1 from a mouse 129SvEv genomic library. The NURR1 gene is approximately 6.2 kb long and is organized into 7 ex...

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Bibliographic Details
Published inGene Vol. 187; no. 1; pp. 135 - 139
Main Authors Saucedo-Cardenas, Odila, Kardon, Rachele, Ediger, Tracy R., Lydon, John P., Conneely, Orla M.
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 10.03.1997
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Summary:NURR1 is an immediate early gene product and a member of the nuclear receptor superfamily of transcription factors. Using the NURR1 cDNA as a probe, we isolated the genomic DNA encoding NURR1 from a mouse 129SvEv genomic library. The NURR1 gene is approximately 6.2 kb long and is organized into 7 exons separated by 6 introns. Structural analysis of the NURR1 reveals that this gene shares a similar structure with that of the nuclear receptor NUR77/NGF1-B. As in NUR77, the promoter region of NURR1 lacks an identifiable TATA box, but is GC-rich. The proximal promoter region also contains an ATF/CREB consensus binding site that may participate in cAMP-mediated induction of this immediate early gene product. Isolation and structural characterization of the NURR1 gene provides information for further developmental and transcriptional regulation studies of this gene.
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ISSN:0378-1119
1879-0038
DOI:10.1016/S0378-1119(96)00736-6