Neuroinflammation of Microglial Regulation in Alzheimer's Disease: Therapeutic Approaches

• Published in: Molecules (Basel, Switzerland) Vol. 29; no. 7; p. 1478
• Main Authors: Chen, Haiyun, Zeng, Yuhan, Wang, Dan, Li, Yichen, Xing, Jieyu, Zeng, Yuejia, Liu, Zheng, Zhou, Xinhua, Fan, Hui
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.04.2024
• Subjects: Advertising executives; Alzheimer Disease - drug therapy; Alzheimer's disease; Anti-inflammatory agents; Anti-Inflammatory Agents - pharmacology; Anti-Inflammatory Agents - therapeutic use; Brain damage; Central Nervous System; Clinical trials; Cytokines; Dementia; Development and progression; Disease; Drugs; Enzymes; FDA approval; Health aspects; Humans; Immune system; Inflammation; Kinases; Lipids; Memory; Metabolism; Microglia; microglial activation; microglial energy metabolic disorder; microglial regulation; neuroinflammation; Neuroinflammatory Diseases; Neurons; Neuropathology; Neurophysiology; Pathogenesis; Pathology; Peptides; Physiology; Proteins; Roles; Tumor necrosis factor-TNF; China; microglial energy metabolic disorder; anti-inflammatory agents; Alzheimer’s disease; neuroinflammation; microglial regulation; microglial activation
• ISSN: 1420-3049; 1420-3049
• DOI: 10.3390/molecules29071478

Alzheimer's disease (AD) is a complex degenerative disease of the central nervous system that is clinically characterized by a progressive decline in memory and cognitive function. The pathogenesis of AD is intricate and not yet fully understood. Neuroinflammation, particularly microglial activation-mediated neuroinflammation, is believed to play a crucial role in increasing the risk, triggering the onset, and hastening the progression of AD. Modulating microglial activation and regulating microglial energy metabolic disorder are seen as promising strategies to intervene in AD. The application of anti-inflammatory drugs and the targeting of microglia for the prevention and treatment of AD has emerged as a new area of research interest. This article provides a comprehensive review of the role of neuroinflammation of microglial regulation in the development of AD, exploring the connection between microglial energy metabolic disorder, neuroinflammation, and AD development. Additionally, the advancements in anti-inflammatory and microglia-regulating therapies for AD are discussed.