Variation in Susceptibility of Bloodstream Isolates of Candida glabrata to Fluconazole According to Patient Age and Geographic Location in the United States in 2001 to 2007

• Published in: Journal of Clinical Microbiology Vol. 47; no. 10; pp. 3185 - 3190
• Main Authors: Pfaller, M.A, Messer, S.A, Hollis, R.J, Boyken, L, Tendolkar, S, Kroeger, J, Diekema, D.J
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society for Microbiology 01.10.2009; American Society for Microbiology (ASM)
• Subjects: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Antifungal Agents - pharmacology; Biological and medical sciences; Candida glabrata; Candida glabrata - drug effects; Candida glabrata - isolation & purification; Candidiasis - microbiology; Child; Child, Preschool; Female; Fluconazole - pharmacology; Fundamental and applied biological sciences. Psychology; Geography; Humans; Infant; Infant, Newborn; Male; Microbial Sensitivity Tests; Microbiology; Middle Aged; Miscellaneous; Mycology; United States; Young Adult; United States; North America; America; Human; Yeast; Fluconazole; Microbiology; Azole derivatives; Candida glabrata; Fungi; Antifungal agent; Sensitivity; Triazole derivatives; Isolate; Fungi Imperfecti; Age
• ISSN: 0095-1137; 1098-660X
• DOI: 10.1128/JCM.00946-09

We examined the susceptibilities to fluconazole of 642 bloodstream infection (BSI) isolates of Candida glabrata and grouped the isolates by patient age and geographic location within the United States. Susceptibility of C. glabrata to fluconazole was lowest in the northeast region (46%) and was highest in the west (76%). The frequencies of isolation and of fluconazole resistance among C. glabrata BSI isolates were higher in the present study (years 2001 to 2007) than in a previous study conducted from 1992 to 2001. Whereas the frequency of C. glabrata increased with patient age, the rate of fluconazole resistance declined. The oldest age group (greater-than-or-equal80 years) had the highest proportion of BSI isolates that were C. glabrata (32%) and the lowest rate of fluconazole resistance (5%).