Incredible Role of Glycerol in Multicomponent Synthesis of 2,3-Dihydroquinazoline-4(1H)-ones and 1-Amidoalkyl-2-naphthols

• Published in: Croatica Chemica Acta Vol. 88; no. 2; pp. 197 - 205
• Main Authors: Hajjami, Maryam, Bakhti, Fariba, Ghiasbeygi, Elahe
• Format: Journal Article Paper
• Language: English
• Published: Zagreb Croatica Chemica Acta 01.07.2015; Croatica Chemica Acta, Croatian Chemical Society; Hrvatsko kemijsko društvo; Croatian Chemical Society
• Subjects: 1-amidoalkyl-2-naphthol; 2,3-dihydroquinazoline-4(1H)-ones; catalyst; Chemical synthesis; Glycerin; Glycerol; glycerosulfonic acid; multicomponent reaction; one-pot; Quinoline; Roles; Studies
• ISSN: 0011-1643; 1334-417X
• DOI: 10.5562/cca2637

An efficient and green synthesis of 1-amidoalkyl-2-naphthols via one-pot three-component condensation of aromatic aldehydes, acetamide and 2-naphthol in the presence of catalytic amounts of glycerosulfonic acid in glycerol as a green solvent was elaborated. Also a simple method for the one-pot three-component synthesis of 2,3-dihydroquinazoline-4(1H)-ones using of isatoic anhydride, aldehydes and ammonium acetate in the presence of glycerol as a green catalyst and solvent was described. In this light we introduced the brilliant and valuable role of glycerol in the synthesis of 2,3-dihydroquinazoline-4(1H)-ones and 1-amidoalkyl-2-naphthols. Keywords: 1-amidoalkyl-2-naphthol, glycerol, glycerosulfonic acid, multicomponent reaction, 2,3-dihydro-quinazoline-4(1#)-ones, one-pot, catalyst