Napsin A and Thyroid Transcription Factor-1-Positive Cerebellar Tumor with Epidermal Growth Factor Receptor Mutation

We present a very rare case of cerebellar metastasis of unknown origin, in which a primary lung adenocarcinoma was diagnosed by pathological examination of a cerebellar metastatic tumor, using immunohistochemical markers and epidermal growth factor receptor (EGFR) mutation of primary lung cancer. A...

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Published inCase reports in oncology Vol. 4; no. 3; pp. 564 - 568
Main Authors Kuwata, Taiji, Iwata, Teruo, Iwanami, Takashi
Format Journal Article
LanguageEnglish
Published Basel, Switzerland S. Karger AG 07.12.2011
Karger Publishers
Subjects
Cerebral metastases
Epidermal growth factor receptor mutation
Lung adenocarcinoma
Published: December 2011
Cerebral metastases
Epidermal growth factor receptor mutation
Lung adenocarcinoma
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Summary:We present a very rare case of cerebellar metastasis of unknown origin, in which a primary lung adenocarcinoma was diagnosed by pathological examination of a cerebellar metastatic tumor, using immunohistochemical markers and epidermal growth factor receptor (EGFR) mutation of primary lung cancer. A 69-year-old woman was admitted to our hospital because of a hemorrhagic cerebellar tumor and multiple small brain tumors. She underwent cerebellar tumor resection. On pathological examination, the tumor was diagnosed as adenocarcinoma. However, the primary tumor site was unidentifiable even with several imaging inspections. On immunohistochemical analysis, the resected tumor was positive for napsin A and thyroid transcription factor-1. In addition, an EGFR mutation was detected in the tumor. Therefore, primary lung cancer was diagnosed and the patient was started on gefitinib (250 mg/day) therapy.
ISSN:1662-6575
1662-6575
DOI:10.1159/000334925