Pulsed-arterial-spin-labeling perfusion 3T MRI following single seizure: A first case report study

• Published in: Epilepsy research Vol. 81; no. 2; pp. 225 - 227
• Main Authors: Pizzini, Francesca, Farace, Paolo, Zanoni, Tiziano, Magon, Stefano, Beltramello, Alberto, Sbarbati, Andrea, Fabene, Paolo F
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 01.10.2008; Elsevier
• Subjects: Adult; Arteries; Biological and medical sciences; Cerebral Cortex - pathology; Cerebral Cortex - physiopathology; Cerebrovascular Circulation - physiology; Epilepsy; Epilepsy - diagnosis; Female; Functional Laterality; Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy; Humans; Hyperperfusion; Hypoperfusion; Investigative techniques, diagnostic techniques (general aspects); Magnetic Resonance Imaging; Medical sciences; Nervous system; Nervous system (semeiology, syndromes); Neurodegeneration; Neuroimaging; Neurology; Radiodiagnosis. Nmr imagery. Nmr spectrometry; Radiopharmaceuticals; Spin Labels; Neuroimaging; Hypoperfusion; Neurodegeneration; Hyperperfusion; Epilepsy; Nervous system diseases; Nuclear magnetic resonance imaging; Cerebral disorder; Case study; Convulsion; Central nervous system disease; Spin labeling; Neurological disorder
• ISSN: 0920-1211; 1872-6844
• DOI: 10.1016/j.eplepsyres.2008.06.009

Summary A 41-year-old woman with focal epilepsy was analyzed immediately and 1 week post-ictally using pulsed-arterial-spin-labeling perfusion 3T MRI, a non-invasive method. Seizure-associated blood flow alterations were characterized by increased ictal perfusion in the occipito-parietal right cortex, and hypoperfusion in the same location 1 week later. These results indicate that non-invasive perfusion MRI can be used routinely to detect vascular alterations in epilepsy, and possibly to identify the location of the seizure focus.