Detection of endometrial intraepithelial neoplasia (EIN) in postmenopausal endometrium
Objectives: To detect the presence of endometrial intraepithelial neoplasia (EIN) in the endometrium of postmenopausal patients. Patients and Methods: Sixty-three postmenopausal patients with endometrial polyps ( n=48), hyperplasia ( n=12) and endometrioid carcinoma ( n=3) were enrolled for this stu...
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Published in | Maturitas Vol. 46; no. 2; pp. 153 - 161 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
Shannon
Elsevier Ireland Ltd
20.10.2003
Elsevier Science |
Subjects | |
Online Access | Get full text |
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Summary: | Objectives: To detect the presence of
endometrial intraepithelial neoplasia (EIN) in the endometrium of postmenopausal patients.
Patients and Methods: Sixty-three postmenopausal patients with endometrial polyps (
n=48), hyperplasia (
n=12) and endometrioid carcinoma (
n=3) were enrolled for this study. The diagnosis of EIN was made by using morphological criteria and immunohistochemical methods for detection of PTEN and bcl-2.
Results: EIN lesions were found in cases of endometrial polyp (
n=1), atrophic endometrium (
n=1) and in hyperplasia (
n=1). The glands were packed, showed cytological atypia and were negative for both PTEN and bcl-2. Three patients with endometrial hyperplasia had isolated PTEN-negative glands but they were still bcl-2 positive.
Conclusions: The use of immunohistochemical methods helps detect the presence of EIN in the postmenopausal endometrium but does not substitute the morphological criteria for this diagnosis. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0378-5122 1873-4111 |
DOI: | 10.1016/S0378-5122(03)00186-5 |