Anticancer Potential of Indole Phytoalexins and Their Analogues

• Published in: Molecules (Basel, Switzerland) Vol. 29; no. 10; p. 2388
• Main Authors: Zigová, Martina, Michalková, Radka, Mojžiš, Ján
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.05.2024
• Subjects: Analysis; Angiogenesis; Animals; Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacology; antiproliferative; Apoptosis; Autophagy; Biosynthesis; brassinin; camalexin; Cancer; Care and treatment; Cell cycle; Cell death; Cell Proliferation - drug effects; Defense industry; Health aspects; Humans; indole phytoalexins; Indoles - chemistry; Indoles - pharmacology; Kinases; Lee, J.H; Leukemia; Medical research; Medicine, Experimental; Metabolites; Metastasis; Neoplasms - drug therapy; Neoplasms - metabolism; Pathogens; Phytoalexin; Phytoalexins; Prostate; Proteins; Sesquiterpenes - chemistry; Sesquiterpenes - pharmacology; Sulfur; Thiazoles - chemistry; Thiazoles - pharmacology; Thiocarbamates - chemistry; Thiocarbamates - pharmacology; cancer; brassinin; indole phytoalexins; antiproliferative; camalexin
• ISSN: 1420-3049; 1420-3049
• DOI: 10.3390/molecules29102388

Indole phytoalexins, found in economically significant family plants, are synthesized in response to pathogen attacks or stress, serving as crucial components of plant defense mechanisms against bacterial and fungal infections. Furthermore, recent research indicates that these compounds hold promise for improving human health, particularly in terms of potential anticancer effects that have been observed in various studies. Since our last comprehensive overview in 2016 focusing on the antiproliferative effects of these substances, brassinin and camalexin have been the most extensively studied. This review analyses the multifaceted pharmacological effects of brassinin and camalexin, highlighting their anticancer potential. In this article, we also provide an overview of the antiproliferative activity of new synthetic analogs of indole phytoalexins, which were synthesized and tested at our university with the aim of enhancing efficacy compared to the parent compound.