Alterations of acute phase reaction and cytokine production in patients following severe burn injury

• Published in: Burns Vol. 28; no. 6; pp. 535 - 542
• Main Authors: Dehne, Marius G, Sablotzki, Armin, Hoffmann, Andreas, Mühling, Jörg, Dietrich, Friedrich E, Hempelmann, Gunter
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 01.09.2002; Elsevier Science
• Subjects: Acute-Phase Proteins - analysis; Acute-Phase Reaction - blood; Adult; Analysis of Variance; Biological and medical sciences; Burn injury; Burns; Burns - blood; Calcitonin - blood; Calcitonin Gene-Related Peptide; Cytokines; Cytokines - biosynthesis; Cytokines - blood; Enzyme-Linked Immunosorbent Assay; Female; Humans; Male; Medical sciences; Middle Aged; MODS; Procalcitonin; Prospective Studies; Protein Precursors - blood; SIRS; Time Factors; Traumas. Diseases due to physical agents; SIRS; Cytokines; MODS; Burn injury; Procalcitonin; Burn; Human; Prospective; Phase; Immune response; Pathophysiology; Acute; Cytokine; Production; Alteration; Severe; Trauma
• ISSN: 0305-4179; 1879-1409
• DOI: 10.1016/S0305-4179(02)00050-5

To determine the acute immunologic reaction, mediated by cytokines, interleukines (ILs) and growth factors and the susceptibility to infections and sepsis after severe burn injury a prospective, single unit, longitudinal study of acute phase reactants and mediators who performed. After approval by the ethics committee of our hospital, we investigated the plasma concentrations of IL-2, -6, -8, -10, and -13, the soluble IL-2 receptor (sIL-2R), and the acute phase proteins procalcitonin (PCT) and C-reactive protein (CRP) at admission and every 3 days in 24 patients over a time course of 28 days after thermal injury and categorized by percent burn: ≤30% (group 1; n=12) and >30% (group 2; n=12). Shortly after burn injury we found higher concentrations of IL-2, -6, -10 and PCT in those patients >30% TBSA. During the study period, we found significant higher levels of acute phase proteins, IL-6 and -8 in patients >30% TBSA. The incidence of SIRS and MODS was three times increased in patients >30% TBSA. Our results show different patterns of cytokines and acute phase proteins in patients with different burned surface areas over a long time and continuous monitoring of a more distinct inflammatory response in these patients.