Synthesis and biological evaluation of water-soluble organogermanium

• Published in: European journal of medicinal chemistry Vol. 45; no. 4; pp. 1654 - 1656
• Main Authors: Choi, Sumi, Oh, Changwon, Han, Jeongsoo, Park, Jina, Choi, Jee-Hye, Min, Na Young, Lee, Kwang-Ho, Park, Ae Ja, Kim, Yeo Jin, Jang, Su Jeong, Lee, Duck-Hyung, Ham, Seung Wook
• Format: Journal Article
• Language: English
• Published: PARIS Elsevier Masson SAS 01.04.2010; Elsevier
• Subjects: Animals; Biological and medical sciences; Chemistry, Medicinal; Drug Evaluation, Preclinical; Germanium - chemistry; Germanium - pharmacology; Immune modulator; Immunomodulators; Interferon; Life Sciences & Biomedicine; Magnetic Resonance Spectroscopy; Mass Spectrometry; Medical sciences; Mice; Organic Chemicals - chemical synthesis; Organic Chemicals - pharmacology; Organogermanium; Pharmacology & Pharmacy; Pharmacology. Drug treatments; Science & Technology; Solubility; Water - chemistry; Immune modulator; Interferon; Organogermanium; CELLS; PROPAGERMANIUM; GERMANIUM SESQUIOXIDE; MACROPHAGES; GE-132; FACTS; Germanium Organic compounds; Aldose; Rodentia; Cytokine; Oral administration; Biological activity; Water soluble compound; Vertebrata; Mammalia; Mouse; Animal; Interferon inducer; Glycoside; Organic germane; Pharmacokinetics; Chemical synthesis; Gamma interferon
• ISSN: 0223-5234; 1768-3254
• DOI: 10.1016/j.ejmech.2009.12.069

Interferon (INF) is an effective drug in treating several human diseases. Ge-132, which is the most common and well-studied organic germanium, has been reported to induce INF-γ and has undergone clinical trials with promising preclinical results. However, it has been reported that long-term ingestion or high doses of organic Ge-132 causes similar toxic effects as GeO 2 because Ge-132 can be easily contaminated with significant amounts of inorganic germanium during the preparation. In this study, we synthesized the water-soluble organogermanium compound (Ge–OH) without possible contamination with toxic inorganic germanium and showed that Ge–OH is a better INF-γ inducer than Ge-132 by an animal study. New water-soluble organogermanium compound (Ge–OH) was synthesized. An animal study showed that Ge–OH is a better INF-γ inducer than Ge-132 [Display omitted] .