Ivacaftor-Induced Proteomic Changes Suggest Monocyte Defects May Contribute to the Pathogenesis of Cystic Fibrosis

[...]although studies in mice may be less affected by secondary disease manifestations, they may be complicated by species differences. Previous work indicates that CF macrophages have decreased LPS receptor endocytosis, and as a consequence, have exaggerated LPS responses (4). [...]defective recept...

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Published inAmerican journal of respiratory cell and molecular biology Vol. 54; no. 4; pp. 594 - 597
Main Authors Hisert, Katherine B, Schoenfelt, Kelly Q, Cooke, Gordon, Grogan, Brenda, Launspach, Jan L, Gallagher, Charles G, Donnelly, Seamas C, Welsh, Michael J, Singh, Pradeep K, McKone, Edward F, Becker, Lev
Format Journal Article
LanguageEnglish
Published United States American Thoracic Society 01.04.2016
Subjects
Aminophenols - pharmacology
Animals
Correspondence
Cystic fibrosis
Cystic Fibrosis - immunology
Cystic Fibrosis - metabolism
Cystic Fibrosis - pathology
Cystic Fibrosis Transmembrane Conductance Regulator - metabolism
Humans
Inflammation
Monocytes - immunology
Ontology
Pathogenesis
Proteins
Proteome - drug effects
Quinolones - pharmacology
Studies
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Summary:[...]although studies in mice may be less affected by secondary disease manifestations, they may be complicated by species differences. Previous work indicates that CF macrophages have decreased LPS receptor endocytosis, and as a consequence, have exaggerated LPS responses (4). [...]defective receptor endocytosis in CF myeloid cells could be a common mechanism that produces both increased LPS and IFNg sensitivity.
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ISSN:1044-1549
1535-4989
DOI:10.1165/rcmb.2015-0322le