Aging and CD8 + T cell immunity to respiratory virus infections

The capacity of the immune system to mediate effective immune responses to pathogens declines with age. In the case of immune responses to newly encountered antigens, several studies have demonstrated that this decline reflects both a loss of naïve T cells and changes in the repertoire and function...

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Bibliographic Details
Published inExperimental gerontology Vol. 42; no. 5; pp. 427 - 431
Main Authors Ely, Kenneth H., Roberts, Alan D., Kohlmeier, Jacob E., Blackman, Marcia A., Woodland, David L.
Format Journal Article
LanguageEnglish
Published England Elsevier Inc 01.05.2007
Subjects
Aging - immunology
CD8 lymphocytes
CD8-Positive T-Lymphocytes - immunology
Humans
Immune response
Immunologic Memory
Influenza
Lung
Memory
Respiratory Tract Infections - immunology
Respiratory Tract Infections - virology
Virus Diseases - immunology
Immune response
Influenza
Memory
Lung
CD8 lymphocytes
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Summary:The capacity of the immune system to mediate effective immune responses to pathogens declines with age. In the case of immune responses to newly encountered antigens, several studies have demonstrated that this decline reflects both a loss of naïve T cells and changes in the repertoire and function of these cells over time. However, comparatively little is known about the impact of age on established memory T cells pools. Here we discuss age-related changes in memory CD8 + T cell pools elicited by influenza and parainfluenza viruses and the impact of these changes on immunity in general.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:0531-5565
1873-6815
DOI:10.1016/j.exger.2006.11.017