Successful Treatment of Plasmacytosis Circumorificialis with Topical Tacrolimus: Two Case Reports and an Immunohistochemical Study

Plasmacytosis circumorificialis (PLC), a benign chronic inflammatory disease with an unknown pathogenesis, is characterized by erythema, erosion nodules and ulcers around the openings of the human body. In this report, we describe two cases of PLC successfully treated with topical tacrolimus. Intere...

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Published inCase reports in dermatology Vol. 5; no. 1; pp. 79 - 83
Main Authors Fujimura, Taku, Furudate, Sadanori, Ishibashi, Masaya, Kambayashi, Yumi, Tojo, Gen-ichi, Wakusawa, Chihiro, Mayama, Hiroshi, Aiba, Setsuya
Format Journal Article
LanguageEnglish
Published Basel, Switzerland S. Karger AG 20.03.2013
Karger Publishers
Subjects
CD163+ macrophages
IL-17
Plasmacytosis circumorificialis
Proinflammatory cytokine
Published: March 2013
Tacrolimus
Plasmacytosis circumorificialis
Tacrolimus
Proinflammatory cytokine
CD163+ macrophages
IL-17
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Summary:Plasmacytosis circumorificialis (PLC), a benign chronic inflammatory disease with an unknown pathogenesis, is characterized by erythema, erosion nodules and ulcers around the openings of the human body. In this report, we describe two cases of PLC successfully treated with topical tacrolimus. Interestingly, immunohistochemical staining revealed that prominent CD163 + proinflammatory macrophages and IL-17-producing cells were infiltrating around plasma cells, which might suggest the reason for the therapeutic effect of topical tacrolimus on PLC.
ISSN:1662-6567
1662-6567
DOI:10.1159/000350184